Letters to the Editor
Vol. 17 No. 1 (2025): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor

Monoclonal gammopathy of neurological significance: a case report and a novel approach

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Received: February 18, 2025
Accepted: April 4, 2025
Published: April 30, 2025
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There is increasing evidence regarding gammopathy of clinical significance (MGCS), conditions in which there is paraprotein-mediated tissue and organ damage via mechanisms independent of tumor growth. There is no standard treatment for these novel entities. We describe a case of a 61 years old male presenting with a monoclonal gammopathy of neurological significance (MGNS) treated with four weekly doses of Rituximab (RTX), without benefit, and then with a novel protocol. 

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“Monoclonal gammopathy of neurological significance: a case report and a novel approach” (2025) Mediterranean Journal of Hematology and Infectious Diseases, 17(1), p. e2025034. doi:10.4084/MJHID.2025.034.