Fecal microbiota transplantation as a salvage therapy for concomitant resistant digestive graft versus host disease and cryptosporidiosis in a patient post hematopoietic stem cell transplant : about a case

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Thomas Finotto
a:1:{s:5:"en_US";s:20:"CHU Clermont-ferrand";}

Carole Chevenet
CHU Clermont-ferrand

Amandine Fayard
CHU Clermont-ferrand

Keywords

Allogeneic haemopietic stem stell transplantation , re-admission, length of stay, healthcare and personalized medical care, Graft versus host disease, cryptosporidiosis

Abstract

Chronic myeloid leukemia (CML) is a hematologic malignancy characterized by an uncontrolled proliferation of myeloid cells, particularly neutrophils. It is revealed through the detection of a Philadelphia chromosome (BCR;ABL).


While tyrosine kinase inhibitors have dramatically improved short and middle-term outcomes, in some resistant or relapsing cases, allogeneic hematopoietic stem cell transplantation (HSCT) can be a curative option.


In this first-ever documented case, we report the successful use of fecal microbiota transplantation (FMT) to treat both corticosteroid-resistant gastrointestinal GvHD and concomitant cryptosporidiosis, leading to significant clinical improvement in a patient post umbilical cord blood HSCT.

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References

1. Legrand F, Grenouillet F, Larosa F et al. Diagnosis and treatment of digestive cryptosporidiosis in allogeneic haematopoietic stem cell transplant recipients: a prospective single centre study Bone Marrow Transplant. 2011, 46(6):858-62


2. La Hoz R et al. Intestinal parasites including Cryptosporidium, Cyclospora, Giardia, and Microsporidia, Entamoeba histolytica, Strongyloides, Schistosomiasis, and Echinococcus: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice Clinical transplant. 2019, 33(9):e13618

3. Staffas A et al. The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease Blood 2017, 129(8):927-933


4. Kaito S, Toya T et al. Fecal microbiota transplantation with frozen capsules for a patient with refractory acute gut graft-versus-host disease. Blood Adv. 2018, 2(22):3097-3101

5. Kakihana K, Fujioka Y et al. Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut. Blood 2016, 128(16):2083-2088

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Published
Apr 30, 2025
DOI https://doi.org/10.4084/MJHID.2025.035

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How to Cite

Finotto, T., Chevenet, C. and Fayard, A. (2025) “Fecal microbiota transplantation as a salvage therapy for concomitant resistant digestive graft versus host disease and cryptosporidiosis in a patient post hematopoietic stem cell transplant : about a case”, Mediterranean Journal of Hematology and Infectious Diseases, 17(1), p. e2025035. doi: 10.4084/MJHID.2025.035.
Issue
Vol. 17 No. 1 (2025): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
Section
Letters to the Editor
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