Clinical spectrum and genotypes of children with alpha-thalassemia in northeastern, Thailand
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Abstract
Alpha-thalassemia is a common inherited hemoglobin disorder. Hemoglobin H (Hb H) disease, a form of alpha-thalassemia caused by the inactivation of three α-globin genes through deletional or non-deletional mutations, presents with a broad clinical spectrum, ranging from non-transfusion-dependent thalassemia (NTDT) to transfusion-dependent thalassemia (TDT).
Objective:
To characterize the clinical manifestations and genetic diversity of alpha-thalassemia in pediatric patients.
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Nattakarn Sangkha, Khon Kaen University
Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Arunee Jetsrisuparp, Khon Kaen University
Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine,
Khon Kaen University, Khon Kaen, Thailand
Kunanya Suwannaying1 Suwannaying, Khon Kaen University
Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine,
Khon Kaen University, Khon Kaen, Thailand
Goonnapa Fucharoen, Khon Kaen University
Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand
Napat Laoaroon, Khon Kaen University
Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine,
Khon Kaen University, Khon Kaen, Thailand