Scientific Letters
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases
Concordance Rate of Fasting Plasma Glucose (PG) and 2-hour PG post Oral Glucose Tolerance Test (OGTT) in Patients with new diagnosis of Thalassemia-Related Diabetes Mellitus (Th-RDM):Implications for Clinical Practice
OGTT concordance rate in thalassemia major
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: November 9, 2025
Accepted: December 15, 2025
Accepted: December 15, 2025
42
Views
25
Downloads
Authors
Accredited Private Hospital Quisisana, Italy.
Pediatric Growth and Development Research Center, Institute of Endocrinology, Iran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of.
Department of Haematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman., Oman.
Emeritus Professor of Pediatric Nephrology, Ain Shams University; Head of the Department of Pediatrics, BUC (Badr University in Cairo), Cairo, Egypt., Egypt.
Department of Pediatric Division of Endocrinology, Hamad General Hospital, Doha, Qatar, Qatar.
Shiraz Endocrinology and Metabolism Research Center, Shiraz, Iran., Iran, Islamic Republic of.
Pediatric Hematology Oncology Department, American Hospital, Dubai, UAE, United Arab Emirates.
Department of Diabetes and Endocrinology, Whittington Hospital, University College London, London, UK., United Kingdom.
Not requested as Scientific Letter
De Sanctis V, Daar S, Soliman AT, Tzoulis P, Karimi M, Salvatore Di Maio S, Kattamis C. Screening for glucose dysregulation in β-thalassemia major (β-TM): An update of current evidences and personal experience. Acta Biomed.2022;93 (1): e2022158. https://doi.org/ 10.23750/abm.v93i1.12802
Khamseh EM, Malek M, Hashemi-madani N, Ghassemi F, Rahimian N, Ziaee A,Foroughi-Gilvaee MR, Faranoush P, Sadighnia N, Elahinia A, Rezvany MR, Saeedi V, Faranoush M . Guideline for the diagnosis and treatment of diabetes mellitus in patients with transfusion-dependent thalassemia. Iran J Blood Cancer. 2023;15(4):293-303.https://doi.org/not available
De Sanctis V, Soliman AT, Elsedfy H, AL Yaarubi S, Skordis N, Khater D, El Kholy M, Stoeva I, Fiscina B, Angastiniotis M, Daar S, Kattamis C. The ICET-A recommendations for the diagnosis and management of disturbances of glucose homeostasis in thalassemia major patients. Mediterr J Hematol Infect Dis.2016; 8 (1): e2016058. https://doi.org/10.4084/mjhid.2016.058
Faranoush P, Elahinia A, Ziaee A, Faranoush M. Review of endocrine complications in transfusion-dependent thalassemia. Iran J Blood Cancer.2023;15(4):212-235. https://doi.org/ not available
American Diabetes Association Professional Practice Committee; 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2025. Diabetes Care. 2025;48 (Supplement 1): S27–S49. https://doi.org/10.2337/dc25-S002
Sato Y, Ohfusa H, Katakura M, Komatsu M, Yamada S, Yamauchi K, Ichikawa K, Aizawa T, Hashizume K. A problem with the diagnosis of diabetes mellitus based on fasting plasma glucose. Diabet. Med. 2002; 19(1):82–83. https://doi.org/10.1046/j.1464-5491.2002.676_4.x
Gatling W, Begley JP. Diagnosing diabetes mellitus in clinical practice: is fasting plasma glucose a good initial test? Practical Diabetes Int. 2001;18(3); 89–93. https://doi.org/not available
Huang J, Ou HY, Karnchanasorn R, Samoa R, Chuang LM, Chiu KC, Feng W. Clinical implication of fasting and post-challenged plasma glucose in diagnosis of diabetes mellitus. Endocrine. 2015; 48 (2): 511–518. https://doi.org/10.1155/2016/6195494
Center for Disease Control and Prevention. Use and interpretation of the WHO and CDC growth charts for children from birth to 20 years in the United States 2014. Available online: https://www.cdc. gov/ nccdp hp/ dnpa/growth charts/resources/ growthchart.pdf (accessed on 1 February 2023).
De SanctisV, Soliman AT, Daar S, Tzoulis P, Di Maio S, Kattamis C. Oral glucose tolerance test: how to maximize its diagnostic value in children and adolescents. Acta Biomed. 2022;93 (5): e2022318. https://doi.org/10.23750/abm.v93i5.13615
Swinscow TDV. Statistics at square one. XVI-The chi squared 2 tests. BMJ.1976;2:573–574. https://doi.org/doi.org/10.1136/ bmj.2. 6035. 573
McDonald GW, Fisker GF, Burnham C. Reproducibility of the oral glucose tolerance test. Diabetes.1965;14:473–480. https://doi.org/10.2337/diab.14.8.473
Ricós C, Alvarez V, Cava F, García-Lario JV, Hernández A, Jiménez CV, Minchinela J, Perich C, Simón M. Current databases on biological variation: pros, cons and progress. Scand J Clin Lab Invest. 1999;59 (7): 491-500. doi: 10.1080/00365519950185229
Ahuja V, Aronen P, Pramodkumar TA, Looker H, Chetrit A, Bloigu AH, Juutilainen A, Bianchi C, La Sala L, Anjana RM, Pradeepa R, Venkatesan U, Jebarani S, Baskar V, Fiorentino TV, Timpel P, DeFronzo RA, Ceriello A, Del Prato S, Abdul-Ghani M, Keinänen-Kiukaanniemi S, Dankner R, Bennett PH, Knowler WC, Schwarz P, Sesti G, Oka R, Mohan V, Groop L, Tuomilehto J, Ripatti S, Bergman M, Tuomi T. Accuracy of 1-hour plasma glucose during the oral glucose tolerance test in diagnosis of type 2 diabetes in adults: a meta-analysis. Diabetes Care.2021;44(4):1062–1068. https://doi.org/10.2337/dc20-1688
Bergman M, Buysschaert M, Ceriello A, Hussain A, Mohan V, Sesti G, Tuomilehto J. Current diagnostic criteria identify risk for type 2 diabetes too late. Lancet Diabetes Endocrinol.2023;11(4): 224-226 . https://doi.org/10.1016/S2213-8587(23) 00039-6
Manco M, Mari A, Petrie J, Mingrone G, Balkau B; EGIR-RISC study group. One hour post- load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort. Diabetologia. 2019;62(3):544-548. https://doi.org/10.1007/s00125-018-4798-5
De Sanctis V, Soliman AT, Tzoulis P, Daar S, Pozzonon GC, Kattamis C . A study of isolated hyperglycemia (bloodglucose≥ 155 mg/dL) at 1-hour of oral glucose tolerance test (OGTT) in patients with β-transfusion dependent thalassemia (β-TDT) followed for 12 years. Acta Biomed. 2021;92 (4):e 2021322. https://doi.org/10.23750/abm.v92i4.11105
Ollerton RL, Playle R, Ahmed K, Dunstan FD, Luzio SD, Owens DR. Day-to-day variability of fasting plasma glucose in newly diagnosed type 2 diabetic subjects. Diabetes Care.1999;22(3):394–398 https://doi.org/ 10.2337 /diacare. 22.3.394
Thewjitcharoen Y, Elizabeth AE, Butade S, Nakasatien S, Chotwanvirat P, Wanothayaroj E, Krittiyawong S, Himathongkam T, Himathongkam T. Performance of HbA1c versus oral glucose tolerance test (OGTT) as a screening tool to diagnose dysglycemic status in high-risk Thai patients. BMC Endocr Dis. 2019;19:23.https://doi.org/doi.org/ 10.1186/s12902-019-0339-6
Mahmoud AA, El-Hawy MA, Allam ET, Salem AH, Hola AS. HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia. Pediatr Res.2024;96 (5):1292-1298. https://doi.org/doi.org/ 10.1038/ s41390-024-03146-y
Ethics Approval
Scientific letterHow to Cite
“Concordance Rate of Fasting Plasma Glucose (PG) and 2-hour PG post Oral Glucose Tolerance Test (OGTT) in Patients with new diagnosis of Thalassemia-Related Diabetes Mellitus (Th-RDM):Implications for Clinical Practice: OGTT concordance rate in thalassemia major” (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026011. doi:10.4084/MJHID.2026.011.
Copyright (c) 2026 Vincenzo De Sanctis, Mohammad Faranoush, Shahina Daar, Ihab Elhakim, Ashraf T Soliman, Forough Saki, Mehran Karimi, Ploutarchos Tzoulis


This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.






