Letters to the Editor
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases

Seven-Year Course of Hypoplastic Myelodysplastic Syndrome Unmasked by Secondary and Neurosyphilis.

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Published: February 28, 2026
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Background:  Myelodysplastic syndrome (MDS) comprises a group of clonal myeloid neoplasms characterized by ineffective hematopoiesis, chronic cytopenias, and the potential for transformation to acute myeloid leukaemia .  Environmental factors such as toxins, drugs, and infections can mimic dysplasia or exert selective pressure on mutated haematopoietic stem cells; however, persistent bone‑marrow failure after eradication of infection is uncommon. 

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Citations

Garcia Manero G, et al. Myelodysplastic syndromes: 2023 update on diagnosis, risk stratification, and management. Am J Hematol 2023;98:1307–1325.
CDC – Sexually Transmitted Infections Treatment Guidelines (2021; updated 2024).
Hormaechea Agulla D, Matatall KA, Le DT, et al. Chronic infection drives DNMT3A loss of function clonal hematopoiesis via IFNγ signaling. Cell Stem Cell 2021;28:1428 1442.
Khadija Rafiq et al. The immunobiology of myelodysplastic neoplasms: a mini review. Frontiers in Immunology 2024;15:1419807.
National Cancer Institute (NCI). Myelodysplastic Syndromes Treatment (PDQ®️) – Health Professional Version. Updated 19 Sep 2024.
Centers for Disease Control and Prevention (CDC). Notes from the Field: Neurosyphilis, Ocular Syphilis, and Otosyphilis — Chicago, January–October 2023.
Medscape Reference. Myelodysplastic Syndrome (MDS) Treatment & Management (updated 14 Jun 2024).

How to Cite



“Seven-Year Course of Hypoplastic Myelodysplastic Syndrome Unmasked by Secondary and Neurosyphilis”. (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026026. doi:10.4084/MJHID.2026.026.