Scientific Letters
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases
Mapping Three Decades of Research on Southeast Asian Ovalocytosis: A Bibliometric Analysis
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: April 30, 2026
0
Views
0
Downloads
0
HTML
Authors
Southeast Asian Ovalocytosis (SeAO) is a hereditary red blood cell membrane disorder occurring at high frequency among Austronesian populations in Southeast Asia, with prevalence estimates in Malaysia ranging from 4% to 30%, particularly among Malay and indigenous populations. We conducted a bibliometric analysis of Scopus-indexed publications to systematically map global research trends, impact, collaborations, and thematic evolution in Southeast Asian Ovalocytosis, identifying knowledge gaps and guiding future translational priorities.
Downloads
Download data is not yet available.
Citations
1. Nixon CP, Satyagraha AW, Baird GL, Harahap A, Panggalo LV, Ekawati LL, Sutanto I, Syafruddin D, Baird J. Accurate light microscopic diagnosis of South-East Asian ovalocytosis. International Journal of Laboratory Hematology. 2018;40(6):655-662.
2. Flatt JF, Stevens-Hernandez CJ, Cogan NM, Eggleston DJ, Haines NM, Heesom KJ, Picard V, Thomas C, Bruce LJ. Expression of South East Asian Ovalocytic Band 3 Disrupts Erythroblast Cytokinesis and Reticulocyte Maturation. Frontiers in Physiology. 2020;11:357.
3. Lavinya AA, Razali RA, Razak MA, Mohamed R, Moses EJ, Soundararajan M, Bruce LJ, Eswaran J, Yusoff NM. Homozygous Southeast Asian Ovalocytosis in five live-born neonates. Haematologica. 2021;106(6):1758-1761.
4. de Meulenaere K, Prajapati SK, Villasis E, Cuypers B, Kattenberg JH, Kasian B, Laman M, Robinson LJ, Gamboa Vilela D, Laukens K, Rosanas-Urgell A. Band 3–mediated Plasmodium vivax invasion is associated with transcriptional variation in PvTRAg genes. Frontiers in cellular and infection microbiology. 2022;12:12:1011692.
5. Gunaratne W, Dissanayake D, Jayaratne K, Premawardhana NP, Siribaddana S. A case series of distal renal tubular acidosis, Southeast Asian ovalocytosis and metabolic bone disease. BMC Nephrology. 2020;21(1):327.
6. Piwkham D, Pattanapanyasat K, Noulsri E, Klaihmon P, Bhoophong P, Prachongsai I. The in vitro red blood cell microvesiculation exerts procoagulant activity of blood cell storage in Southeast Asian ovalocytosis. Heliyon. 2023;9(1):e12714.
7. Chai JF, Kao SL, Wang C, Jun-Yu-Lim V, Khor IW, Dou J, Podgornaia AI, Chothani S, Cheng CY, Sabanayagam C, Wong TY, van Dam RM, Liu J, Reilly DF, Paterson AD, Sim X. Genome-wide association for HbA1c in malay identified deletion on SLC4A1 that influences hba1c independent of glycemia. Journal of Clinical Endocrinology and Metabolism. 2020;105(12):3854-3864.
8. Jarolím P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu SC. Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Proceedings of the National Academy of Sciences of the United States of America. 1991;88(24):11022-11026.
9. Tanner MJA. The structure and function of band 3 (AE1): Recent developments (review). Mol Membr Biol. 1997;14(4):155-165.
10. Bertocchio JP, Genetet S, Da Costa L, Walsh SB, Knebelmann B, Galimand J, Bessenay L, Guitton C, de Lafaille R, Vargas-Poussou R, Eladari D, Mouro-Chanteloup I. Red Blood Cell AE1/Band 3 Transports in Dominant Distal Renal Tubular Acidosis Patients. Kidney International Reports. 2020;5(3):348-357.
11. Yamsri S, Kawon W, Duereh A, Fucharoen G, Fucharoen S. Southeast Asian Ovalocytosis and Hemoglobinopathies in Newborns: Prevalence, Molecular, and Hematologic Analyses. Journal of Pediatric Hematology/Oncology. 2021;43(3):e341-e345.
12. Kalli AC, Reithmeier RAF. Organization and Dynamics of the Red Blood Cell Band 3 Anion Exchanger SLC4A1: Insights From Molecular Dynamics Simulations. Frontiers in Physiology. 2022;13:13:817945.
13. Frías-Ordóñez JS, Urrego Díaz JA, Lozano-Triana CJ, Landínez-Millán G. Distal renal tubular acidosis: case series report and literature review. Rev Colomb Nefrol. 2020;7(1):97-112.
Ethics Approval
Southeast Asian Ovalocytosis, Bibliometric analysisSupporting Agencies
Sultan Ahmad Shah Medical Centre @ IIUMHow to Cite
“Mapping Three Decades of Research on Southeast Asian Ovalocytosis: A Bibliometric Analysis” (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026036. doi:10.4084/MJHID.2026.036.
Copyright (c) 2026 Muhd Alwi Muhd Helmi, Nor Zamzila Abdullah, Ahmad Marzuki Omar, Nour El Huda Abd Rahim, Norlelawati A. Talib
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
