Scientific Letters
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases
Simultaneous presentation of Hemophagocytic Lymphohistiocytosis and Classical Hodgkin's Lymphoma in a patient with underlying germline homozygous STXBP2 Mutation.
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: April 30, 2026
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Hemophagocytic lymphohistiocytosis (HLH) is a severe, life-threatening, hyperinflammatory syndrome characterised by excessive immune activation that leads to multi-organ failure. HLH can be primary (genetic, common in paediatrics) or secondary (triggered by infections, autoimmune diseases, or malignancies, such as Hodgkin's lymphoma). We report a challenging case of a young adult presenting with HLH, subsequently diagnosed with Classical Hodgkin's lymphoma (CHL), and ultimately found to have a homozygous mutation in syntaxin-binding protein 2 (STXBP2) linked to familial hemophagocytic lymphohistiocytosis (FHL). This case highlights the complex interplay between immune mechanisms and malignancy.
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Citations
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How to Cite
“Simultaneous presentation of Hemophagocytic Lymphohistiocytosis and Classical Hodgkin’s Lymphoma in a patient with underlying germline homozygous STXBP2 Mutation”. (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026043. doi:10.4084/MJHID.2026.043.
Copyright (c) 2026 Dr Shilpa Gupta, Dr Amrita Rajendran , Dr Akanksha Chichra , Dr Ayubali Qureshi
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
