Letters to the Editor
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases

Interpreting MRD and Chimerism After Allogeneic Transplantation for Acute Leukemia

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Published: September 1, 2026
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Citations

1. Öksüz SBT, Seval GC, Dalva K, Toprak SK. Post-transplant relapse in acute leukemia: comparative value of MRD and chimerism. Mediterr J Hematol Infect Dis. 2026;18(1):e2026028. https://doi.org/10.4084/MJHID.2026.028
2. Loke J, McCarthy N, Jackson A, Siddique S, Hodgkinson A, Mason J, Crawley C, Gilleece M, Peniket A, Protheroe R, Kirkland K, Craddock C. Posttransplant MRD and T-cell chimerism status predict outcomes in patients who received allografts for AML/MDS. Blood Adv. 2023;7(14):3666-3676. https://doi.org/10.1182/bloodadvances.2022009493
3. Heuser M, Freeman SD, Ossenkoppele GJ, Buccisano F, Hourigan CS, Ngai LL, Tettero JM, Bachas C, Baer C, Béné MC, Bücklein V, Czyz A, Denys B, Dillon R, Feuring-Buske M, Guzman ML, Haferlach T, Jorgensen JL, Kern W, Lacombe F, Maurillo L, Preudhomme C, van der Reijden BA, Thiede C, Venditti A, Vyas P, Wood BL, Walter RB, Döhner K, Roboz GJ, Cloos J. 2021 update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party. Blood. 2021;138(26):2753-2767. https://doi.org/10.1182/blood.2021013626
4. Cloos J, Valk PJM, Thiede C, Döhner K, Roboz GJ, Wood BL, Walter RB, Wang S, Wierzbowska A, Wei AH, Wu D, Vergez F, Venditti A, van der Reijden BA, van de Loosdrecht AA, Tiong IS, Thol FR, Subklewe M, Roumier C, Reuvekamp T, Ravandi F, Preudhomme C, Plesa A, Othman J, Ossenkoppele GJ, Ofran Y, Mimoun A, Maurillo L, Majchrzak A, de Leeuw D, Kern W, Kim DDH, Ikoma-Colturato MRV, Haaksma LH, Guzman ML, Feuring M, Depreter B, Czyz A, Bücklein V, Baer C, Bachas C, Freeman SD, Buccisano F, Hourigan CS, Dillon R, Heuser M. 2025 update on MRD in acute myeloid leukemia: a consensus document from the ELN-DAVID MRD Working Party. Blood. 2026;147(11):1147-1167. https://doi.org/10.1182/blood.2025031480
5. Iacobelli S; EBMT Statistical Committee. Suggestions on the use of statistical methodologies in studies of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 2013;48(Suppl 1):S1-S37. https://doi.org/10.1038/bmt.2012.282
6. Latouche A, Allignol A, Beyersmann J, Labopin M, Fine JP. A competing risks analysis should report results on all cause-specific hazards and cumulative incidence functions. J Clin Epidemiol. 2013;66(6):648-653. https://doi.org/10.1016/j.jclinepi.2012.09.017
7. Giobbie-Hurder A, Gelber RD, Regan MM. Challenges of guarantee-time bias. J Clin Oncol. 2013;31(23):2963-2969. https://doi.org/10.1200/JCO.2013.49.5283

Ethics Approval

Hematology, allogeneic hematopoietic stem cell transplantation, Acute leukemia

Supporting Agencies

None
Naif AlJohani, King Faisal Specialist hospital & Research Center Jeddah Saudi Arabia

Naif I. AlJohani , MD, FRCPC, ABIM, MHCM Harvard is a consultant Leukemia and Transplant Hematologist in the section of Adult Hematology/Cellular Therapy and Transplantation , Department of Oncology , King Faisal Specialist Hospital and research center , Jeddah , Saudi Arabia

How to Cite



“Interpreting MRD and Chimerism After Allogeneic Transplantation for Acute Leukemia” (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026068. doi:10.4084/MJHID.2026.068.