Scientific Letters
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases

Sustained Complete Response to a Short Course of Subcutaneous Daratumumab in Multi-Refractory Immune Thrombocytopenia

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Published: September 1, 2026
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A woman with primary immune thrombocytopenia (ITP) refractory to corticosteroids, intravenous immunoglobulin (IVIG), rituximab, and two thrombopoietin receptor agonists (TPO-RAs) received a new therapy.

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Citations

Chen Y, Hua Z, Xu Y, Chen J, Wen Q, Sun T, Li H, Liu X, Fu R, Ju M, Xue F, Liu W, Dong H, Gu W, Dai X, Wang W, Chi Y, Pei X, Yang R, Zhang L. Daratumumab in patients with immune thrombocytopenia: a single-center, open-label, phase 2 trial. EClinicalMedicine. 2026;94:103849. https://doi.org/10.1016/j.eclinm.2026.103849
2. Patel PS, Farrugia S, Nunnelee J, Mina S, Godby RC, Go R, Rajkumar SV. Efficacy of CD38-targeted therapy in severe, multi-agent refractory immune thrombocytopenia: a case series. Eur J Haematol. 2026;117(1):279-282. https://doi.org/10.1111/ejh.70180
3. Hu Y, Chen H, Wang Z, Ma J, Dong S, Lin X, Cheng X, Bussel JB, Chen Z, Wu R. Daratumumab in pediatric chronic refractory primary immune thrombocytopenia (ITP): rapid platelet recovery, sustained response, and immune reconstitution dynamics. Am J Hematol. 2026;101(2):384-387. https://doi.org/10.1002/ajh.70148
4. Al-Mashdali AF, Dalol AA, Saleh LH, Aweer RA, Abdulgayoom M, Cherif H, Mohamed SF. Targeting CD38 in immune thrombocytopenia: rationale and a scoping review of daratumumab. Blood Rev. 2026:101409. https://doi.org/10.1016/j.blre.2026.101409
5. Tsykunova G, Holme PA, Tran HTT, Frederiksen H, Tjønnfjord E, Munthe LA, Drivet E, Kared H, Sørvoll IH, Ahlen MT, Mahévas M, Michel M, Bussel J, Kuter DJ, Anderson Tvedt TH, Ghanima W. Safety and efficacy of daratumumab in immune thrombocytopenia. Blood Adv. 2026;10(1):143-154. https://doi.org/10.1182/bloodadvances.2025017279

Ethics Approval

Immune thrombocytopenia (ITP). Autoimmune hematologic disorders. Biologic therapies. Thrombopoietin receptor agonists. FcRn inhibitors. B-cell targeted therapy. Treatment sequencing. Hematology

Supporting Agencies

None

How to Cite



“Sustained Complete Response to a Short Course of Subcutaneous Daratumumab in Multi-Refractory Immune Thrombocytopenia” (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026069. doi:10.4084/MJHID.2026.069.