Scientific Letters
Vol. 18 No. 1 (2026): Mediterranean Journal of Hematology and Infectious Diseases
https://doi.org/10.4084/MJHID.2026.080

Acute fulminant Clostridium-Perfrigens sepsis with massive intravascular hemolysis in a young woman with sickle cell disease. Case presentation and review of the literature

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Published: October 31, 2026
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sickle cell disease, asplenia, infection, sepsis, hemolysis, clostridium perfrigens

Authors

Lorenza Torti
lorenza.torti21@gmail.com
1) Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Rome, Italy., Italy.
Mauro Polzoni
2) Department of Anesthesiology, Sant'Eugenio Hospital, Rome, Italy., Italy.
Nicolina Ardu
1) Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Rome, Italy., Italy.
Laura Maffei
1) Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Rome, Italy., Italy.
Beatrice Basso
3) Department of Haematology, University of Rome Tor Vergata, Rome, Italy., Italy.
Maria Ilaria Del Principe
1) Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Rome, Italy. 3) Department of Haematology, University of Rome Tor Vergata, Rome, Italy., Italy.

To the Editor

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single amino acid substitution at the sixth residue of the beta (β)-globin subunit (p.Glu6Val)

Vaso-occlusion, hemolytic anemia and vasculopathy are the hallmarks of SCD pathophysiology, leading to high morbility and mortality.

 

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Ethics Approval

sickle cell disease, sepsis, asplenia, clostridium perfrigens, hemolysis

Supporting Agencies

None. No specific funding was received for this study.

How to Cite



“Acute fulminant Clostridium-Perfrigens sepsis with massive intravascular hemolysis in a young woman with sickle cell disease. Case presentation and review of the literature” (2026) Mediterranean Journal of Hematology and Infectious Diseases, 18(1), p. e2026080. doi:10.4084/MJHID.2026.080.
Copyright (c) 2026 Lorenza Torti, Mauro Polzoni, Nicolina Ardu, Laura Maffei, Beatrice Basso, Maria Ilaria Del Principe Creative Commons License

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