Mediterranean Journal of Hematology and Infectious Diseases

About the Journal

The Mediterranean Journal of Hematology and Infectious Diseases was founded by Giuseppe Leone, Professor of Hematology at the Catholic University of Rome, in 2009, with the collaboration of Prof. Eligio Pizzigallo, Infectivologist, and Prof. Luigi Maria Larocca, Pathologist.

ANNOUNCEMENTS

New Articles (July/August 2025). Free online of Mediterranean Journal of Hematology and Infectious Diseases 2025-06-29

Review articles: 2

Original Articles: 4

Scientific Letters: 2

Letters to the Editor: 2

Article May/June 2025 2025-05-01

Review articles, Original Articles, Scientific Letters, Letters to the Editor

MJHID Reviewers 2024 2025-03-20

Thanks to MJHID Reviewers

CURRENT ISSUE

Published: 2025-01-01

Vol. 17 No. 1 (2025): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor

Review Articles

HEPARIN-BINDING PROTEIN AS A DIAGNOSTIC AND PROGNOSTIC MARKER OF INFECTIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Wenshan Yang, Wei Dong

Abstract 488 | PDF Downloads 432 HTML Downloads 48 Suppl. Files Downloads 258

Page e2025029

PDF HTML Suppl. Files

DOI: https://doi.org/10.4084/MJHID.2025.029

Guest Editor: Pellegrino Musto HOW FIRST-LINE THERAPY IS CHANGING IN NON-TRANSPLANT ELIGIBLE MULTIPLE MYELOMA PATIENTS.

Daniele Derudas

Abstract 706 | PDF Downloads 774 HTML Downloads 51

Page e2025025

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.025

CUPROPTOSIS: A REVIEW ON MECHANISMS, ROLE IN SOLID AND HEMATOLOGICAL TUMORS, AND ASSOCIATION WITH VIRAL INFECTIONS

MAURIZIO MARTINI, Pietro Tralongo, Mariagiovanna Ballato, Vincenzo Fiorentino, Walter Giordano, Valeria zuccalà, Cristina Pizzimenti, Arianna Bakacs, Antonio Ieni, Giovanni Tuccari, Guido Fadda, Luigi Maria Larocca

Abstract 227 | PDF Downloads 232 HTML Downloads 10

Page e2025052

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.052

Guest Editor: Pellegrino Musto BISPECIFIC ANTIBODIES AND CAR T IN MULTIPLE MYELOMA: APPROPRIATE SELECTION OF PATIENTS AND SEQUENCING

Michele Puppi, Ilaria Sacchetti, Katia Mancuso, Paola Tacchetti, Lucia Pantani, ilaria Rizzello, Miriam Iezza, Marco Talarico, Enrica Manzato, Simone Masci, Roberta Restuccia, Simona Barbato, Silvia Armuzzi, Barbara Taurisano, Ilaria Vigliotta, Elena Zamagni

Abstract 664 | PDF Downloads 599 HTML Downloads 69

Page e2025045

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.045

TOXICITIES ASSOCIATED WITH CAR-T CELL THERAPIES

Ugo Testa, Dr. Germana Castelli, Dr. Elvira Pelosi, Dr. Galli, Prof. Patrizia Chiusolo

Abstract 672 | PDF Downloads 628 HTML Downloads 55

Page e2025039

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.039

Guest Editor: Pellegrino Musto HOW FIRST LINE THERAPY IS CHANGING IN TRANSPLANT-ELIGIBLE MULTIPLE MYELOMA PATIENTS

Yasmine Houbaida, Maria Livia Del Giudice, Sara Galimberti, Gabriele Buda

Abstract 844 | PDF Downloads 869 HTML Downloads 59

Page e2025026

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.026

BRUTON’S TYROSINE KINASE (BTK) MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL): A CLINICAL VIEW.

Stefano Molica

Abstract 316 | PDF Downloads 289 HTML Downloads 13

Page e2025053

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.053

WALDENSTRÖM MACROGLOBULINEMIA - A STATE-OF-THE-ART REVIEW: PART 2- FOCUS ON THERAPY

Michele Bibas, Shayna Sarosiek , Jorge Castillo

Abstract 936 | PDF Downloads 1212 HTML Downloads 49

Page e2025015

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.015

Guest Editor: Pellegrino Musto AN UPDATE OF THE APPROPRIATE SEQUENCING FOR SALVAGE THERAPIES IN MULTIPLE MYELOMA

Gregorio Barila', Francesca Rezzonico, Laura Pavan, Alessandro Corso, Renato Zambello

Abstract 512 | PDF Downloads 490 HTML Downloads 79

Page e2025043

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.043

Guest Edtor: Pellegrino Musto NOVELTIES ON MULTIPLE MYELOMA FROM THE MAIN 2024 HEMATOLOGY CONFERENCES

Sonia Morè, Laura Corvatta, Valentina Maria Manieri, Erika Morsia, Antonella Poloni, Massimo Offidani

Abstract 645 | PDF Downloads 763 HTML Downloads 65

Page e2025027

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.027

Guest Editor: Pellegrino Musto REFINING HIGH-RISK MULTIPLE MYELOMA: ADVANCEMENTS IN GENOMIC, CLINICAL, AND PROGNOSTIC CRITERIA

Dr. Enrica A. Martino, Dr. G. Mele, Dr. F. Morabito, Dr. M. Gentile, Dr. E. Vigna

Abstract 1436 | PDF Downloads 1073 HTML Downloads 178

Page e2025006

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.006

PLASMACELL NEOPLASMS WITH SPREADING IN THE BLOOD AND TISSUES: EXTRAMEDULLARY MYELOMA DISEASE A RARE AGGRESSIVE FORM OF MULTIPLE MYELOMA (First of two parts)

Ugo Testa; Giuseppe G.M. Leone

Abstract 1125 | HTML Downloads 173 PDF Downloads 490

Page e2025005

HTML PDF

DOI: https://doi.org/10.4084/MJHID.2025.005

Original Articles

ANALYSIS OF CLINICAL CHARACTERISTICS AND DIAGNOSTIC EFFICACY OF BLOOD INDICATORS IN NEONATAL SEPSIS WITH DIFFERENT PATHOGENIC BACTERIA

You-Hong Duan, Pu Guo, You-Bao Liang, Yao Chen, Zi-Yu Chang

Abstract 144 | PDF Downloads 159 HTML Downloads 12

Page e2025048

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.048

PLASMODIUM VIVAX INFECTIONS IN DUFFY-NEGATIVE INDIVIDUALS: A PARADIGM SHIFT IN INDIAN MALARIA EPIDEMIOLOGY

Roshan Shaikh, Kanjaksha Ghosh, Ajit Gorakshakar

Abstract 390 | PDF Downloads 403 HTML Downloads 38

Page e2025044

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.044

Vaccination Following Leukemia Treatment: Viral Vaccine Responses in Survivors of Acute Lymphoblastic Leukemia

Elif Kilic Konte, Ayca Koca Yozgat, Aysun Kara Uzun, Bahar Cuhaci Cakir, Nese Yarali

Abstract 199 | PDF Downloads 179 HTML Downloads 6

Page e2025049

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.049

HEMATOPOIETIC STEM CELL TRANSPLANTATION IN SEVERE PEDIATRIC SICKLE CELL DISEASE: OUTCOME AND LONG-TERM COMPLICATIONS, SAUDI EXPERIENCE AT KING FAISAL SPECIALIST HOSPITAL, RIYADH, SAUDI ARABIA

Abdullah Al-Jefri, Fatema Al-Hashem, Khawar, Amal Al-Seraihy, Ali Al-Ahmari, Ibrahim Ghemlas, Awatif AlAnazi, Hawazen Al-Saedi, Saadiya Khan, Abdulrahman Al-Musa, Mahasen Saleh, Mouhab Ayas

Abstract 491 | PDF Downloads 486 HTML Downloads 66

Page e2025030

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.030

GROUP-BASED TRAJECTORY MODELING OF PLATELET IN PATIENTS WITH APLASTIC ANEMIA: A STUDY BASED ON THE MIMIC DATABASE

Lang Peng, Lixin Zou, Xiaoliu Liu

Abstract 436 | PDF Downloads 553 Suppl. Files Downloads 423 HTML Downloads 48

Page e2025012

PDF Suppl. Files HTML

DOI: https://doi.org/10.4084/MJHID.2025.012

MOLECULAR CHARACTERIZATION OF EPSTEIN - BARR VIRUS BASED ON EBNA3C PROTEIN AMONG HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS IN JORDAN

Rabaa Athamneh, Hiba Swaity, Waleed Almomani, Hayyan. Taweil , Assia Benbraiek, Anas Khalifeh

Abstract 336 | PDF Downloads 389 HTML Downloads 58

Page e2025032

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.032

SEROLOGICAL AND MOLECULAR DETECTION OF RICKETTSIA SPP STEMMING FROM HEMATOPHAGOUS VECTORS IN PATIENTS WITH MENINGEAL SYNDROME IN NORTHERN ALGERIA

HICHEM GHAOUI, IBRAHIM Nasir ADAM, BASHER Nosiba, TAKFARINAS IDRES, SORAYA TEMIM, ASMA SAAD-DJABALLAH , IDIR BITAM, NASSIMA ACHOUR

Abstract 179 | PDF Downloads 268 HTML Downloads 15

Page e2025046

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.046

T-CELL RECEPTOR (TCR)-VΒ REPERTOIRE FLOW CYTOMETRY FOR T-CELL LYMPHOPROLIFERATIVE DISORDER: A RETROSPECTIVE ANALYSIS OF A SINGLE-CENTER REAL-LIFE LABORATORY EXPERIENCE

Marco Antonacci, Jacopo Micozzi, Alessandro Costa, Alessandro Laganà, Maria Laura Milani, Stefania Intoppa, Vittorio Bellomarino, Maria Grazia Nardacci, Mario Biglietto, Stefano Imperatore, Maria Laura Bisegna, Maurizio Martelli, Irene Della Starza, Maria Stefania De Propris

Abstract 435 | PDF Downloads 521 Suppl. Files Downloads 416 HTML Downloads 44

Page e2025016

PDF Suppl. Files HTML

DOI: https://doi.org/10.4084/MJHID.2025.016

COULD PLASMA GLUCOSE (PG) INCREMENT (PG %) EXPAND THE CLINICAL WEIGHT OF OGTT? PRELIMINARY FINDINGS IN 19 TDT PATIENTS (Β-TDT) WITH NORMAL GLUCOSE TOLERANCE

Vincenzo De Sanctis, Ashraf Soliman, Shahina Daar, Ploutarchos Tzoulis, Christos Kattamis

Abstract 143 | PDF Downloads 153 HTML Downloads 12

Page e2025050

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.050

GREEK CONSENSUS ON CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) TREATMENT

Sotirios Sachanas, Theodoros Vassilakopoulos, Maria Angelopoulou, sotirios Papageorgiou, Emmanouil Spanoudakis, Maria Bouzani, Maria Dimou, Panagiotis Panagiotidis

Abstract 577 | HTML Downloads 51 PDF Downloads 522

Page e2025014

HTML PDF

DOI: https://doi.org/10.4084/MJHID.2025.014

INTEGRATION OF CD200, CD43 AND ROR1 IN MULTIPARAMETER FLOW CYTOMETRY (MFC) ROUTINE PANELS FOR THE DIFFERENTIAL DIAGNOSIS OF B-CELL LYMPHOPROLIFERATIVE DISORDERS (B-LPDS)

Alessandro Laganà, Raffaele Maglione, Alessandro Costa, Biancamaria Mandelli, Maria Laura Bisegna, Maria Laura Milani, Valeria Filipponi, Maria Grazia Nardacci, Tania Soriano, Eugenio Santacroce, Luigi Petrucci, Carla Giordano, Maurizio Martelli, Maria Stefania De Propris

Abstract 1284 | PDF Downloads 989 HTML Downloads 186 PDF Downloads 724

Page e2025.002

PDF HTML PDF

DOI: https://doi.org/10.4084/MJHID.2025.002

IMPACT OF RED CELL EXCHANGE TRANSFUSION ON INFLAMMATORY MARKERS IN SICKLE CELL DISEASE

Adriana Costa, Inês Mendes, Joana Lage, Marta Moniz, Catarina Amorim, Pedro Nunes, Helena Almeida, Carlos Escobar, Ana Ventura, Teresa Ferreira

Abstract 1151 | PDF Downloads 974 HTML Downloads 134

Page e2025011

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.011

CAUSAL RELATIONSHIP BETWEEN HELICOBACTER PYLORI ANTIBODIES AND IMMUNE THROMBOCYTOPENIA: A MENDELIAN RANDOMIZATION STUDY

Yuzhan Chen, Qitian Mu, Guifang Ouyang

Abstract 1006 | PDF Downloads 836 PDF Downloads 679 HTML Downloads 147

Page e2025.003

PDF PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.003

A MULTICENTER ICET-A SURVEY ON ADHERENCE TO ANNUAL ORAL GLUCOSE TOLERANCE TEST (OGTT) SCREENING IN TRANSFUSION-DEPENDENT THALASSEMIA (TDT) PATIENTS - THE EXPERT CLINICIANS’ OPINION ON FACTORS INFLUENCING THE ADHERENCE AND ON ALTERNATIVE STRATEGIES FOR ADHERENCE OPTIMIZATION

Vincenzo De Sanctis

Abstract 2111 | PDF Downloads 916 HTML Downloads 125

Page e2025008

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.008

Scientific Letters

A case of multiple myeloma in a patient in treatment for chronic lymphocytic leukemia

Mario Biglietto, Ugo Coppetelli, Luciano Fiori, Martina Gherardini, Raffaele Maglione, Alessandro Pulsoni, Azzurra Anna Romeo

Abstract 401 | PDF Downloads 391 HTML Downloads 70

Page e2025033

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.033

Early use of thrombopoietin receptor agonists (Tpo-Ras) in clinical practice: results from an Italian survey on behalf of the GIMEMA Working Group Anemia and Thrombocytopenia

Mariasanta Napolitano, elisa lucchini, maria rosaria de paolis, antonio urso, nicola vianelli, francesco zaja, cristina santoro

Abstract 360 | PDF Downloads 362 HTML Downloads 56

Page e2025041

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.041

Elevated endogenous alveolar carbon monoxide concentration in patients with transfusion-dependent thalassemia and its relation to ineffective erythropoiesis

Yanni Xie

Abstract 119 | PDF Downloads 135 HTML Downloads 4

Page e2025047

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.047

COVID-19 induces prolonged immunological exhaustion leading to relapse of hematological malignancies except in hematopoietic cell transplant recipients

SUPARNO CHAKRABARTI, Snigdha Banerjee, Mahak Agarwal, Gitali Bhagawati, Nilanjan Saha, SARITA JAISWAL

Abstract 437 | PDF Downloads 371 HTML Downloads 59

Page e2025042

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.042

Risk Factors of Hepatitis B Virus Infection in the Kurdistan Region of Iraq: A Cross-Sectional Study

Nawfal R Hussein, Halder J Abozait, Ibrahim A Naqid, Nashwan MR Ibrahim, Fatima K Khalid, Dildar H Musa, Zana SM Saleem

Abstract 592 | PDF Downloads 557 HTML Downloads 69

Page e2025018

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.018

Bladder microbiota snapshots help to monitor urinary tract infections in vulnerable patients

Giulia Santarelli, Delia Mercedes Bianco, Margherita Capriati, Maurizio Sanguinetti, Claudia Rendeli, Flavio De Maio

Abstract 330 | PDF Downloads 370 HTML Downloads 48

Page e2025028

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.028

Long-term persistence of dysplastic features in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and arsenic trioxide

Enrico Santinelli, Maria Rosaria Pascale, Luca Guarnera, Arianna Savi, Flavia Mallegni, Carmelo Gurnari, Luca Maurillo, Maria Teresa Voso, Susanna Fenu

Abstract 381 | PDF Downloads 380 HTML Downloads 45

Page e2025038

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.038

Genetic modulators of diversity in biological expression of sickle cell anemia in patients from democratic republic of Congo

MAMY NGOLE, MAMY NGOLE, GLOIRE MBAYABO, PAUL LUMBALA, VALERIE RACE, NONO MVUAMA, STEPHANIE DEMAN, ERIKA SOUCHE, PROSPER TSHILOBO LUKUSA, CHRIS VAN GEET, KOENRAAD DEVRIENDT, GERT MATTHIJS, AIME LUMAKA, ISABELLE CLEYNEN

Abstract 1021 | HTML Downloads 150 PDF Downloads 756

Page e2025001

HTML PDF

DOI: https://doi.org/10.4084/MJHID.2025.001

Anti-mullerian hormone evaluates ovarian function in patients with non-transfusion-dependent thalassemia

Yan Li, Kun Yang, Yali Zhou, Shiwu Cheng

Abstract 855 | PDF Downloads 826 HTML Downloads 113

Page e2025007

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.007

The diagnostic sensitivity of beta-D-glucan assay in patients with chronic disseminated candidiasis

Hyo Ju Son, Kyung Hwa Jung

Abstract 860 | PDF Downloads 769 PDF Downloads 641 HTML Downloads 91

Page e2025009

PDF PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.009

Case Reports

Leukemia cutis in a patient with acute myeloid leukemia undergoing Azacitidine-Venetoclax: case presentation and review of the literature

Elisa Buzzatti, Cristina Mauro, Caterina Botti, Roberta Presicci, Giovangiacinto Paterno, Raffaele Palmieri, Carmelo Gurnari, Flavia Mallegni, Elisa Meddi, Federico Moretti, Lucia Cardillo, Valeria Mezzanotte, Kristian Taka, Lucrezia De Marchi, Luca Maurillo, Francesco Buccisano, Adriano Venditti, Maria Ilaria Del Principe

Abstract 410 | PDF Downloads 576 HTML Downloads 32

Page e2025013

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.013

Letters to the Editor

Fecal microbiota transplantation as a salvage therapy for concomitant resistant digestive graft versus host disease and cryptosporidiosis in a patient post hematopoietic stem cell transplant : about a case

Thomas Finotto, Carole Chevenet, Amandine Fayard

Abstract 446 | PDF Downloads 434 HTML Downloads 36

Page e2025035

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.035

THE Co-Occurrence of Jak2/Calr-Positive Myeloproliferative Disorder and Bcr-Abl-Positive Chronic Myelogenous Leukaemia Treated with Combination of Tyrosine Kinase Inhibitors and Ruxolitinib.

Katia Paciaroni, Selenia Campagna, Nicoletta Villiva', Enrico Maffini, Francesca Celesti, Attilio Tordi, Mariangela Lombardi, Giulia Dragonetti, Tommaso Caravita di Toritto

Abstract 468 | PDF Downloads 573 HTML Downloads 48

Page e2025023

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.023

Direct oral anticoagulants (DOACs) in the onco-hematologic patients

Mario Biglietto, Silvio Ligia, Alessandro Laganà, Giovanni Manfredi Assanto, Martina Gherardini, Erminia Baldacci, Cristina Santoro, Antonio Chistolini

Abstract 456 | PDF Downloads 568 HTML Downloads 32

Page e2025022

PDF HTML

DOI: https://doi.org/10.4084/MJHID.2025.022