COAGULOPATHY IN BETA-THALASSEMIA: CURRENT UNDERSTANDING AND FUTURE PERSPECTIVES

M. Domenica Cappellini, Khaled M. Musallam, Alessia Marcon, Ali Taher
  • M. Domenica Cappellini
    1Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy, Italy | maria.cappellini@unimi.it
  • Khaled M. Musallam
    2Department of Internal Medicine, Hematology-Oncology Division, American University of,
  • Alessia Marcon
    Affiliation not present
  • Ali Taher
    Affiliation not present

Abstract

As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

Keywords

: thalassemia; hypercoagulability; thromboembolism; stroke.

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Submitted: 2014-06-11 11:31:22
Published: 2009-12-28 00:00:00
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