COAGULOPATHY IN BETA-THALASSEMIA: CURRENT UNDERSTANDING AND FUTURE PERSPECTIVES

M. Domenica Cappellini, Khaled M. Musallam, Alessia Marcon, Ali Taher
  • M. Domenica Cappellini
    1Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy, Italy | maria.cappellini@unimi.it
  • Khaled M. Musallam
    2Department of Internal Medicine, Hematology-Oncology Division, American University of,
  • Alessia Marcon
    Affiliation not present
  • Ali Taher
    Affiliation not present

Abstract

As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

Keywords

: thalassemia; hypercoagulability; thromboembolism; stroke.

Full Text:

PDF
HTML
Submitted: 2014-06-11 11:31:22
Published: 2009-12-28 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
120

Views:
PDF
86
HTML
6190

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Comments on this article

View all comments


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006] is owned by the U.C.S.C. and it is published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185