Toxic epidermal necrolysis associated with severe cytomegalovirus infection in a patient on regular hemodialysis.

Dina Khalaf, Bassem Toema, Nidal Dabbour, Fathi Jehani
  • Bassem Toema
    Saad Specialist Hospital, Saudi Arabia
  • Nidal Dabbour
    Saad Specialist Hospital, Saudi Arabia
  • Fathi Jehani
    Affiliation not present

Abstract

Primary illness with cytomegalovirus leads to latent infection with possible reactivations especially in the immunocompromised patients. Toxic epidermal necrolysis is an immune mediated cytotoxic reaction.

A fifty years old female diabetic hypertensive patient with end stage renal disease was admitted with fever of unknown origin, constitutional symptoms, vague upper gastrointestinal symptoms and skin rash. Upper gastrointestinal endoscopic biopsy confirmed her diagnosis with cytomegalovirus esophagitis and duodenitis. Cytomegalovirus immunoglobulin M and immunoglobulin G levels were negative but polymerase chain reaction showed fulminant viremia. Biopsy of the skin rash was consistent with toxic epidermal necrolysis. Despite treatment with Ganciclovir, intravenous immunoglobulins, and granulocyte colony stimulating factor the patient’s condition rapidly deteriorated and she died due to multiorgan failure, disseminated intravascular coagulopathy and overwhelming sepsis.

Probably there is a true association linking toxic epidermal necrolysis to fulminant reactivation of cytomegalovirus. The aim of this anecdote is reporting a newly recognized presentation of cytomegalovirus.

Full Text:

PDF
HTML
Submitted: 2014-06-12 16:04:25
Published: 2011-01-04 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
297

Views:
PDF
59
HTML
15933

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185