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GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS

Angela Stoddart, Megan E. McNerney, Elizabeth Bartom, Rachel Bergerson, David J. Young, Zhijian Qian, Jianghong Wang, Anthony A. Fernald, Elizabeth M. Davis, Richard A. Larson, Kevin P. White, Michelle M. Le Beau

Authors information
  • Angela Stoddart
    Affiliation not present.
  • Megan E. McNerney
    Affiliation not present.
  • Elizabeth Bartom
    Affiliation not present.
  • Rachel Bergerson
    Affiliation not present.
  • David J. Young
    Affiliation not present.
  • Zhijian Qian
    Affiliation not present.
  • Jianghong Wang
    Affiliation not present.
  • Anthony A. Fernald
    Affiliation not present.
  • Elizabeth M. Davis
    Affiliation not present.
  • Richard A. Larson
    Affiliation not present.
  • Kevin P. White
    Affiliation not present.

Abstract


Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy.  t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell.  The prognosis for patients with t-MN is poor, as current forms of therapy are largely ineffective.  Cytogenetic analysis, molecular analysis and gene expression profiling analysis of t-MN has revealed that there are distinct subtypes of the disease; however, our understanding of the genetic basis of t-MN is incomplete.  Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies.

Keywords


therapy-related myeloid neoplasms, genetic pathways, cytogenetic abnormalities, del(5q)

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Submitted: 2014-06-12 16:03:06
Published: 2011-05-16 00:00:00
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