LOW INCIDENCE RATE OF OPPORTUNISTIC AND VIRAL INFECTIONS DURING IMATINIB TREATMENT IN CHRONIC MYELOID LEUKEMIA PATIENTS IN EARLY AND LATE CHRONIC PHASE

Massimo Breccia, Corrado Girmenia, Roberto Latagliata, Giuseppina Loglisci, Michelina Santopietro, Vincenzo Federico, Luigi Petrucci, Alessandra Serrao, Adriano Salaroli, Giuliana Alimena
  • Corrado Girmenia
    Hematology-Sapienza University, Italy
  • Roberto Latagliata
    Hematology-Sapienza University, Italy
  • Giuseppina Loglisci
    Hematology-Sapienza University, Italy
  • Michelina Santopietro
    Hematology-Sapienza University, Italy
  • Vincenzo Federico
    Hematology-Sapienza University, Italy
  • Luigi Petrucci
    Hematology-Sapienza University, Italy
  • Alessandra Serrao
    Hematology-Sapienza University, Italy
  • Adriano Salaroli
    Hematology-Sapienza University, Italy
  • Giuliana Alimena
    Hematology-Sapienza University, Italy

Abstract

Background: Imatinib has become first line therapy in chronic myeloid leukemia patients. Little is known about the infective consequences during the treatment with this drug in large series of chronic phase patients.

Material and methods: From January 2001 to September 2006 we treated with imatinib 250 patients in first line (early CP) or after interferon failure (late CP), out of clinical trials and recorded all the bacterial and viral infections occurred.

Results: We recorded a similar incidence of bacterial and viral infections both in first line and late CP patients (respectively, 16% and 13%) during 3.5 years of follow-up. Analysis of presenting features predisposing to infections revealed differences only in late CP patients, with elevated percentage of high Sokal risk patients and a more longer median time from diagnosis to start of imatinib.

Conclusions: Opportunistic infections and reactivation of Herpes Zoster are observed during imatinib therapy at very low incidence.

Keywords

chronic myeloid leukemia, imatinib, infections, bacterial, herpes Zoster

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Submitted: 2014-06-12 16:03:54
Published: 2011-05-16 00:00:00
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