EPIDEMIOLOGY OF PROTHROMBIN G20210A MUTATION IN THE MEDITERRANEAN REGION

Mehrez M. Jadaon
  • Mehrez M. Jadaon
    Mehrez M. Jadaon Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait P.O. Box 31470 – Sulaibekaht 90805 – Kuwait Tel.: (965) 6664 3485 Fax: (965) 2498 3835 Email: mehrez@hsc.edu.kw mehrezmls99@yahoo.com, Kuwait | mehrez@hsc.edu.kw

Abstract

There are many genetic and acquired risk factors that are known to cause venous thromboembolic disorders (VTE). One of these is the Prothrombin G20210A mutation, which has been identified in 1996. Prothrombin G20210A mutation causes higher levels of the clotting factor prothrombin in the blood of carriers, which creates a higher tendency towards blood clotting (hypercoagulability), and therefore the carriers become at higher risk of developing VTE. High prevalence of Prothrombin G20210A mutation was reported in Caucasian populations, but the prevalence was almost absent in non-Caucasians. That was most obvious in countries of South Europe and the Mediterranean region. This review article discusses Prothrombin G20210A mutation, how it causes VTE, the origin of the mutation, and its distribution worldwide with special concentration on the Mediterranean area.

Keywords

Thrombosis, Familiar Thrombophilia ,

Full Text:

PDF
HTML
Submitted: 2014-06-12 16:02:37
Published: 2011-11-28 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
577

Views:
PDF
116
HTML
1480

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006] is owned by the U.C.S.C. and it is published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185