BIOLOGY OF HUMAN MALARIA PLASMODIA INCLUDING PLASMODIUM KNOWLESI

Spinello Antinori, Laura Galimberti, Laura Milazzo, Mario Corbellino
  • Spinello Antinori
    Department of Clinical Science L Sacco, Section of Infectious Diseases and Immunopathology Università degli Studi di Milano Via GB Grassi 74 20157, Milano, Italy, Italy | spinello.antinori@unimi.it
  • Laura Galimberti
    Department of Clinical Science L Sacco, Section of Infectious Diseases and Immunopathology Università degli Studi di Milano Via GB Grassi 74 20157, Milano, Italy,
  • Laura Milazzo
    Department of Clinical Science L Sacco, Section of Infectious Diseases and Immunopathology Università degli Studi di Milano Via GB Grassi 74 20157, Milano, Italy, Italy
  • Mario Corbellino
    Department of Clinical Science L Sacco, Section of Infectious Diseases and Immunopathology Università degli Studi di Milano Via GB Grassi 74 20157, Milano, Italy, Italy

Abstract

Malaria is a vector-borne infection caused by unicellular parasite of the genus Plasmodium. Plasmodia are obligate intracellular parasites that in humans after a clinically silent replication phase in the liver are able to infect and replicate within the erythrocytes. Four species (P.falciparum, P.malariae, P.ovale and P.vivax) are traditionally recognized as responsible of natural infection in human beings but the recent upsurge of P.knowlesi malaria in South-East Asia has led clinicians to consider it as the fifth human malaria parasite. Recent studies in wild-living apes in Africa have revealed that P.falciparum, the most deadly form of human malaria, is not only human-host restricted as previously believed and its phylogenetic lineage is much more complex with new species identified in gorilla, bonobo and chimpanzee. Although less impressive, new data on biology of P.malariae, P.ovale and P.vivax are also emerging and will be briefly discussed in this review.

Keywords

.falciparum, P.knowlesi, P.malariae, P.ovale, P.vivax; biology; malaria

Full Text:

PDF
HTML
Submitted: 2014-06-13 09:28:30
Published: 2012-03-09 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
829

Views:
PDF
294
HTML
25618

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006] is owned by the U.C.S.C. and it is published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185