DIAGNOSTIC VALUE OF SIMULTANEOUS MEASUREMENT OF PROCALCITONIN, INTERLEUKIN-6 AND HS CRP IN PREDICTION OF EARLY-ONSET NEONATAL SEPSIS

alireza abdollahi, saeed shoar, fatemeh nayyeri, mamak shariat
  • saeed shoar
    Division of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, Iran, Iran, Islamic Republic of
  • fatemeh nayyeri
    Division of Neonatalogy, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, Iran,
  • mamak shariat
    Division of Neonatalogy, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, Iran,

Abstract

Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations .We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive- C reactive protein in prediction of early neonatal sepsis.

We performed a follow- up study on 95 neonates who were below 12 hours (h) of age, had clinical signs of sepsis or maternal risk factors for sepsis. Neonates were assigned to 4 groups including “proven early-onset sepsis”, “clinical early-onset sepsis”, “negative infectious status”, and “uncertain infectious status”. Blood samples were obtained within the first 12 h of birth repeated between 24 hours and 36 hours of age for determination of serum levels of PCT, IL-6, high sensitivie- C Reactive Protein (hs-CRP), and white blood cell (WBC) count.

On admission, neonates with sepsis had a higher WBC count, IL-6, PCT, and hs-CRP levels compared with those neonates without sepsis. This remained significant even after 12-24 hours of admission. Also, patients with clinical evidences of sepsis had a higher serum level of PCT and IL-6 within 12-24 hours after admission compared to the patients with uncertain sepsis. In final The combination of IL-6, hs-CRP, and PCT seems to be predictive in diagnosis of early onset neonatal sepsis.

Keywords

Procalcitonin; interleukin-6; high sensitive- CRP; early neonatal sepsis

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Submitted: 2014-06-13 09:31:19
Published: 2012-05-06 00:00:00
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