Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Darcie M Deaver, Mojdeh Naghashpour, Lubomir Sokol
  • Darcie M Deaver
    Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States |
  • Mojdeh Naghashpour
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States
  • Lubomir Sokol
    H Lee Moffitt Cancer Center and Research Institute, United States


Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue.  There is a higher incidence of KFD in women aged 20-35 years and in Asian populations.  A PubMed search revealed 590 articles that described KFD.  Of these, 22 cases have been fully described in the United States.  Ten of the 22 (45%) patients were male and 12 (55%) were female, with 20% Caucasian, 20% Asian American, and the remaining 60% of other ethnic backgrounds.  In this study, we describe an additional 3 cases of KFD and discuss the diagnosis, pathology, and management of KFD.


Kikuchi-Fujimoto Disease; lymphadenopathy; systemic lupus erythmatous

Full Text:

Submitted: 2014-07-21 14:10:06
Published: 2013-12-31 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Comments on this article

View all comments

Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy