Kikuchi-Fujimoto Disease in the United States: Three Case Reports and Review of the Literature

Darcie M Deaver, Mojdeh Naghashpour, Lubomir Sokol
  • Darcie M Deaver
    Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States |
  • Mojdeh Naghashpour
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States
  • Lubomir Sokol
    H Lee Moffitt Cancer Center and Research Institute, United States


Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disease that manifests primarily as cervical lymphadenopathy but may include low-grade fever, headache, and fatigue.  There is a higher incidence of KFD in women aged 20-35 years and in Asian populations.  A PubMed search revealed 590 articles that described KFD.  Of these, 22 cases have been fully described in the United States.  Ten of the 22 (45%) patients were male and 12 (55%) were female, with 20% Caucasian, 20% Asian American, and the remaining 60% of other ethnic backgrounds.  In this study, we describe an additional 3 cases of KFD and discuss the diagnosis, pathology, and management of KFD.


Kikuchi-Fujimoto Disease; lymphadenopathy; systemic lupus erythmatous

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Submitted: 2014-07-21 14:10:06
Published: 2013-12-31 00:00:00
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