Postpandemic influenza A/H1N1pdm09 is still causing severe perinatal complications

Hein Bogers, Dominique Bos, Sam Schoenmakers, Johannes J Duvekot
  • Hein Bogers
    Erasmus MC, University Medical Centre Rotterdam, the Netherlands Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Netherlands
  • Dominique Bos
    Erasmus MC, University Medical Centre Rotterdam, the Netherlands Department of Obstetrics and Gynaecology, Division of Obstetrics, Netherlands
  • Sam Schoenmakers
    Erasmus MC, University Medical Centre Rotterdam, the Netherlands Department of Obstetrics and Gynaecology, Division of Obstetrics, Netherlands
  • Johannes J Duvekot
    Erasmus MC, University Medical Centre Rotterdam, the Netherlands Department of Obstetrics and Gynaecology, Division of Obstetrics, Netherlands | j.j.duvekot@erasmusmc.nl

Abstract

Although influenza A/H1N1pdm09 is not causing a pandemic anymore, we recently observed two critically ill pregnant women infected by this virus. We present these cases to illustrate the possible severe complications of an – at that moment – seasonal influenza in pregnancy. We discuss the epidemiological differences between the pandemic and postpandemic phase and try to explain the high virulence of H1N1-infections in pregnancy by discussing insights in immunology during pregnancy. We conclude that although the influenza A/H1N1pdm09 is in the postpandemic phase, infection by this influenza virus still needs to be considered in pregnant women with progressive respiratory dysfunction.

Keywords

Critical Care; Influenza A Virus, H1N1 Subtype; Infection; Pandemics; Pregnancy

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Submitted: 2014-10-06 15:10:02
Published: 2014-12-20 00:00:00
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