Fetal hemoglobin modifies the disease manifestation of severe Plasmodium falciparum malaria in adult patients with sickle cell anemia.

Prasanta Purohit
  • Prasanta Purohit
    Senior Research Fellow Indian Council of Medical Research (ICMR) Sickle Cell Clinic and Molecular Biology Laboratory, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Odisha, India | prasanta.biochem@gmail.com

Abstract

Sickle cell anemia (SCA) and Plasmodium falciparum malaria are two major public health problems in the state of Odisha, India. The prevalence of sickle cell gene in the western part of Odisha is 13.1%,1P. falciparum contributes 23% of cases and 15% of malaria-related deaths in India. Various......

Keywords

Plasmodium falciparum, Malaria, Sickle Cell Anemia, HbF

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Submitted: 2016-07-10 17:55:14
Published: 2016-11-01 00:00:00
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References

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Mmbando BP, Mgaya J, Cox SE, et al., Negative Epistasis between sickle and foetal haemoglobin suggests a reduction in protection against malaria. PLoS ONE. 2015; 10(5): e0125929.

World Health Organization: Guidelines for the Treatment of Malaria, 2nd ed. Geneva, World Health Organization, 2010 (who.int/malaria/publications/atoz/9789241547925/en/.)

Mashon RS, Dash PM, Khalko J, et al., Higher fetal hemoglobin concentration in patients with sickle cell disease in eastern India reduces frequency of painful crisis. European Journal of Hematology. 2009; 83(4):383-384.

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