Respiratory function in pediatric African SCA patients underwent bone marrow transplantation

Antonella Isgrò, Javid Gaziev, Marco Marziali, Katia Paciaroni, Gioia De Angelis, Cecilia Alfieri, Michela Ribersani, Festus Olusola Olowoselu, Guido Lucarelli
  • Javid Gaziev
    Affiliation not present
  • Marco Marziali
    Affiliation not present
  • Katia Paciaroni
    Affiliation not present
  • Gioia De Angelis
    Affiliation not present
  • Cecilia Alfieri
    Affiliation not present
  • Michela Ribersani
    Affiliation not present
  • Festus Olusola Olowoselu
    Affiliation not present
  • Guido Lucarelli
    Affiliation not present


Children with sickle cell anemia (SCA) are prone to invasive infections caused by S. pneumonia, H. influenzae, and Plasmodium falciparum. The presence of asthma increases the risk of mortality, and it has been shown an association between the presence of bronchial hyperactivity and the onset of acute chest syndrome. Like thalassemia, allogeneic hematopoietic stem cell transplantation (HSCT) is curative in most individuals with SCA. We report pulmonary function analyzed by spirometry, before and after transplantation, in a group of Nigerian SCA children. Our results indicate that restrictive pulmonary pattern (RVP) is a common finding in these patients. Although we do not observe significant improvements in lung function after 3-6 months of transplantation, it is useful to perform a spirometric evaluation of these patients at the time of transplant.


Sickle cell anemia, children, spirometry, transplant, asthma.

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Submitted: 2017-01-08 12:20:33
Published: 2017-04-15 00:00:00
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