Genomic integration of HHV-6 mimicking viral reactivation after autologous stem cell transplantation

rossana mineri, Jacopo Mariotti, Barbara Sarina, Lucio Morabito, roberto crocchiolo, stefania bramanti, tiziana sarno, federica tordato, carmelo carlo-stella, armando santoro, Luca Castagna
  • Jacopo Mariotti
    Hematology Unit, Humanitas Cancer Center, Italy
  • Barbara Sarina
    Hematology Unit, Humanitas Cancer Center, Italy
  • Lucio Morabito
    Hematology Unit, Humanitas Cancer Center, Italy
  • roberto crocchiolo
    Hematology Unit, Humanitas Cancer Center, Italy
  • stefania bramanti
    Hematology Unit, Humanitas Cancer Center, Italy
  • tiziana sarno
    Molecular Biology Section Humanitas Clinical and Research Center, Italy
  • federica tordato
    Infectious Disease Unit, Humanitas Clinical and Research Center, Italy
  • carmelo carlo-stella
    Hematology Unit, Humanitas Cancer Center, Italy
  • armando santoro
    Hematology Unit, Humanitas Cancer Center,
  • Luca Castagna
    Hematology Unit, Humanitas Cancer Center,

Abstract

The monitoring of HHV-6 after allogeneic hematopoietic stem cell transplantation (HSTC) has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous HSCT is not well-characterized, although viral reactivation might be responsible for significant complications even after autologous HSCT. Here we report for the first time to our knowledge the case of a patient with genomic integration of HHV-6, presenting with high titers of HHV-6 after autologous HSCT, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the genomic integration and allowed the discontinuation of the antiviral treatment to the patient.  This case might be helpful for discriminate HHV-6 reactivation from viral integration, thus avoiding unnecessary and potentially toxic antiviral therapy once the genomic integration is confirmed.

Keywords

virus infection and Hematology

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Submitted: 2017-10-03 19:06:56
Published: 2018-02-15 00:00:00
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