Leukocyte derived chemotaxin 2 (ALECT2) amyloidosis

Main Article Content

Uday P Kulkarni
Anna Valson
Anila Korula
Vikram Mathews

Keywords

Amyloidosis, ALECT2, renal amyloid, ethnic variation, treatment

Abstract

We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and Immunofixation were normal, with mildly elevated serum free light chain ratio. Renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid.

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