Original Articles
Vol. 8 (2016): Review, Original Articles, Case Reports
https://doi.org/10.4084/mjhid.2016.018

CANDIDA ASSOCIATED BLOODSTREAM INFECTIONS IN PEDIATRIC HEMATOLOGY PATIENTS: SINGLE CENTER EXPERIENCE

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Received: November 26, 2015
Accepted: February 17, 2016
Published: March 1, 2016
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Fungal infection, neutropenia, leukemia
Hematology, infectious diseases

Authors

Dilek Gurlek Gokcebay
drdilekgurlek@hotmail.com
Ankara Children’s Hematology and Oncology Hospital, Türkiye.
Nese Yarali
Ankara Children’s Hematology and Oncology Hospital, Türkiye.
Pamir Isik
Ankara Children’s Hematology and Oncology Hospital, Türkiye.
Cengiz Bayram
Ankara Children’s Hematology and Oncology Hospital, Türkiye.
Aslinur Ozkaya-Parlakay
Ankara Children’s Hematology and Oncology Hospital, .
Abdurrahman Kara
Ankara Children’s Hematology and Oncology Hospital, Türkiye.
Bahattin Tunç
Ankara Children’s Hematology and Oncology Hospital, Türkiye.

Background and Objectives: Candida-associated bloodstream infections are frequent and potentially life-threatening conditions in hematology patients. The aim of this study is to evaluate the characteristics, risk factors, and outcome of Candida-associated bloodstream infections in children with hematological diseases at a children’s hospital.

Methods: The medical records of the patients with hematological diseases and hematopoietic stem cell transplantation (HSCT) recipients who were diagnosed as Candida-associated bloodstream infection between February 2010 and February 2014 were reviewed retrospectively.

Results: Thirty episodes of candidemia involving 26 patients (38% female, and 62% male) with median age of 7 years (range; 1 to 17) were noted. Infections with non-albicans Candida spp. occurred more frequently (63%) and C. krusei was the predominant microorganism among non-albicans Candida spp. (37%). Candida albicans was isolated from 11 of the 30 episodes (37%). Twenty-three of the patients (88%) had central venous catheter (CVC) prior to candidemia, and they were removed in 16 of the 30 episodes (53%). Isolated Candida spp, underlying disease and status of the disease, presence of mucositis, neutropenia, using of broad spectrum antibiotics, corticosteroids or total parenteral nutrition were not identified as predictors of outcome. However patients whose CVCs had not been removed were more likely to die than those whose had been removed (54% vs. 6%, respectively; p=0.012).

Conclusions: Candida-associated bloodstream infections in children with hematological diseases and HSCT recipients were common particularly in patients with CVCs. Beside appropriate antifungal therapy, CVC removal improves the outcome of candidemia in children with hematological disease. 

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Original articles

Supporting Agencies

No financial support
Dilek Gurlek Gokcebay, Ankara Children’s Hematology and Oncology Hospital
Pediatric hematology
Nese Yarali, Ankara Children’s Hematology and Oncology Hospital
Pediatric hematology
Pamir Isik, Ankara Children’s Hematology and Oncology Hospital
Pediatric hematology
Cengiz Bayram, Ankara Children’s Hematology and Oncology Hospital
Pediatric hematology
Aslinur Ozkaya-Parlakay, Ankara Children’s Hematology and Oncology Hospital
Pediatric Infectious Diseases
Abdurrahman Kara, Ankara Children’s Hematology and Oncology Hospital
Pediatric hematology
Bahattin Tunç, Ankara Children’s Hematology and Oncology Hospital
Pediatric hematology

How to Cite



“CANDIDA ASSOCIATED BLOODSTREAM INFECTIONS IN PEDIATRIC HEMATOLOGY PATIENTS: SINGLE CENTER EXPERIENCE” (2016) Mediterranean Journal of Hematology and Infectious Diseases, 8, p. e2016018. doi:10.4084/mjhid.2016.018.