COAGULOPATHY IN BETA-THALASSEMIA: CURRENT UNDERSTANDING AND FUTURE PERSPECTIVES

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M. Domenica Cappellini *
Khaled M. Musallam
Alessia Marcon
Ali Taher
(*) Corresponding Author:
M. Domenica Cappellini | maria.cappellini@unimi.it

Abstract

As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.


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Author Biography

M. Domenica Cappellini, 1Universitá di Milano, Policlinico Foundation IRCCS, Milan, Italy

Institute of Hematology, Catholic University, Director