Rubella associated with hemophagocytic syndrome. First report in a male and review of the literature

Makram Koubaa, Chakib Marrakchi, Imed Mâaloul, Saloua Makni, Lamia Beraajah, Moez Elloumi, Boussaima Hammami, Dorra Lahiani, Tahia Boudawara, Mounir Ben Jemâa
  • Chakib Marrakchi
    Affiliation not present
  • Imed Mâaloul
    Affiliation not present
  • Saloua Makni
    Affiliation not present
  • Lamia Beraajah
    Affiliation not present
  • Moez Elloumi
    Affiliation not present
  • Boussaima Hammami
    Affiliation not present
  • Dorra Lahiani
    Affiliation not present
  • Tahia Boudawara
    Affiliation not present
  • Mounir Ben Jemâa
    Affiliation not present


A 22-year-old man was admitted to our hospital because of fever, skin rash and epistaxis. Physical examination revealed fever (39.5°C), generalized purpura, lymphadenopathy and splenomegaly. Blood tests showed pancytopenia. Bone marrow aspiration and biopsy showed hemophagocytosis with no evidence of malignant cells. Anti rubella IgM antibody were positif and the IgG titers increased from 16 to 50 UI/mL in 3 days. Therefore, he was diagnosed to have rubella-associated hemophagocytic syndrome. We report herein the first case in a man and the sixth case of rubella-associated hemophagocytic syndrome in the literature by search in Pub Med till March 2012.


Rubella; Male; Hemophagocytic syndrome

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Submitted: 2014-06-13 09:33:50
Published: 2012-08-09 00:00:00
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