VASCULAR ENDOTHELIAL GROWTH FACTOR IN CHILDREN WITH THALASSEMIA MAJOR PDF

Main Article Content

sameh samir fahmey
Pediatrics Department ,Beni Suef University

Hassan Naguib
Pediatrics Department ,Beni Suef University

sanna Abdelshafy
clinical pathology Department ,Beni Suef University

rasha Alashry
Pediatrics Department ,Beni Suef University

Keywords

anemia, angiogenesis, splenectomy, thalassemia major

Abstract

Background: The ?-Thalassemia syndromes are the most common hereditary chronic hemolytic anemia due to impaired globin chain synthesis.  Vascular endothelial growth factor (VEGF) plays several roles in angiogenesis which is a crucial process in the pathogenesis of several inflammatory, autoimmune and malignant diseases .Endothelial damage and inflammation make a significant contribution to the pathophysiology of ?-thalassemia.

Purpose: The aim of the study was to assess serum VEGF level in children with beta-thalassemia major as a marker of angiogenesis.

Methods: Blood samples were collected from 40 patients with thalassemia major and 10 healthy controls and assayed for VEGF by enzyme-linked immunosorbent assay.

Results: VEGF level was significantly higher in patients with ?-Thalassemia major than healthy controls (p=0.001).In addition, VEGF level was higher in splenectomised thalassemic patients than non splenectomised ones (p=0.001) .However, there were a positive correlation between VEGF and chelation starting age (p=0.008) and a negative correlation between VEGF and frequency of blood transfusion (p=0.002).

Conclusion: thalassemia patients, especially splenectomized, have elevated serum levels of VEGF. Early chelation and regular blood transfusion help to decrease serum VEGF and the risk of angiogenesis.

 

Downloads

Download data is not yet available.
Abstract 887 | PDF Downloads 506 HTML Downloads 945 Figure 1 the correlation between frequency of blood transfusion and serum vascular endothelial growth factor (VEGF). Downloads 0

Article Sidebar

PDF HTML Figure 1 the correlation between frequency of blood transfusion and serum vascular endothelial growth factor (VEGF).
Published
Jun 5, 2013
DOI https://doi.org/10.4084/mjhid.2013.044

Article Details

How to Cite

fahmey, sameh samir, Naguib, H., Abdelshafy, sanna and Alashry, rasha (2013) “VASCULAR ENDOTHELIAL GROWTH FACTOR IN CHILDREN WITH THALASSEMIA MAJOR PDF”, Mediterranean Journal of Hematology and Infectious Diseases, 5(1), p. e2013044. doi: 10.4084/mjhid.2013.044.
Issue
Vol. 5 No. 1 (2013): Reviews, Articles, Case Reports and Letters
Section
Original Articles

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers. Authors will grant copyright of their articles to the Institute of Hematology, Catholic University, Rome . No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.