Status Epilepticus Due to Severe HHV-6 Encephalitis in an Allogeneic Stem Cell Transplant Recipient

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Poorvi Chordia
Pranatharthi H Chandrasekar *
(*) Corresponding Author:
Pranatharthi H Chandrasekar | pchandrasekar@med.wayne.edu

Abstract

Reactivation of human herpes virus-6 (HHV-6) after stem cell transplantation occurs frequently. It is associated with clinical manifestations varying from nonspecific symptoms such as fevers or rash, to severe life threatening complications including post-transplantation limbic encephalitis. We report a case of severe HHV-6 encephalitis with viremia in an allogeneic peripheral stem cell transplant recipient who presented with status epilepticus unresponsive to antiepileptic therapy.  With intravenous ganciclovir and supportive care, the patient’s condition improved. Awareness of HHV-6 infection in stem cell transplant recipients may help with early diagnosis and improved outcome.


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Author Biographies

Poorvi Chordia, Wayne State University

Fellow

Infectious Diseases

Pranatharthi H Chandrasekar, Wayne State University, School of Medicine

Professor of Medicine

Internal Medicine, Division of Infectious Diseases