EARLY AND LATE COMPLICATIONS RELATED TO CENTRAL VENOUS CATHETERS IN HAEMATOLOGICAL MALIGNANCIES: A RETROSPECTIVE ANALYSIS OF 1102 PATIENTS

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Salvatore Giacomo Morano *
Lorenzo Coppola
Roberto Latagliata
Paola Berneschi
Antonio Chistolini
Alessandra Micozzi
Corrado Girmenia
Massimo Breccia
Gregorio Brunetti
Angela Matturro
Giovanni Rosa
Pietro Guerrisi
Franco Mandelli
Roberto Foà
Giuliana Alimena
(*) Corresponding Author:
Salvatore Giacomo Morano | morano@bce.uniroma1.it

Abstract

Several severe complications may be associated with the use of central venous catheters (CVC). We retrospectively evaluated on a large cohort of patients the incidence of CVC-related early and late complications. From 7/99 to 12/2005, 1102 CVC have been implanted at our Institution in 881 patients with haematological malignancies (142,202 total day number of implanted CVC). Early mechanic complications were 79 (7.2% - 0.55/1,000 days/CVC). Thirty-nine episodes of early infective complications (<1 week from CVC implant) occurred (3.5% - 0.3/1000 days/CVC): furthermore, 187 episodes of CVC-related sepsis (17% - 1.3/1000 days/CVC) were recorded. There were 29 episodes (2.6%) of symptomatic CVC-related thrombotic complications, with a median interval from CVC implant of 60 days (range 7 – 395). The rate of CVC withdrawal due to CVC-related complications was 26%. The incidence of CVC-related complications in our series is in the range reported in the literature, notwithstanding cytopenia often coexisting in haematological patients.


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Author Biographies

Salvatore Giacomo Morano, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Lorenzo Coppola, Hematology “AOU” Sassari, Italy

Roberto Latagliata, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Paola Berneschi, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Antonio Chistolini, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Alessandra Micozzi, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Corrado Girmenia, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Massimo Breccia, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Gregorio Brunetti, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Angela Matturro, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Giovanni Rosa, Dipartimento Anestesia e Rianimazione, Azienda Policlinico Umberto I, "Sapienza" Università di Roma

Pietro Guerrisi, Dipartimento Scienze Radiologiche, Azienda Policlinico Umberto I, "Sapienza" Università di Roma

Franco Mandelli, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Roberto Foà, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)

Giuliana Alimena, Department of Cellular Biotechnology and Hematology ‘La Sapienza’ University Via Benevento 6, IT–00161 Rome (Italy)