Leukocyte derived chemotaxin 2 (ALECT2) amyloidosis

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Uday P Kulkarni *
Anna Valson
Anila Korula
Vikram Mathews
(*) Corresponding Author:
Uday P Kulkarni | upkulkarni@gmail.com

Abstract

We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and Immunofixation were normal, with mildly elevated serum free light chain ratio. Renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid.


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Author Biographies

Uday P Kulkarni, Christian Medical College, Vellore, Tamil Nadu, India - 632004

Senior PG Registrar in Clinical Haematology

Anna Valson, Christian Medical College, Vellore, Tamil Nadu, India - 632004

Associate Professor of Nephrology

Anila Korula, Christian Medical College, Vellore, Tamil Nadu, India - 632004

Professor of General Pathology

Vikram Mathews, Christian Medical College, Vellore, Tamil Nadu, India - 632004

Professor and Head, Department of Clinical Haematology

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