Massive pulmonary embolism at the onset of acute promyelocytic leukemia

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Federica Sorà
Patrizia Chiusolo
Luca Laurenti


acute promyelocytic leukemia, pulmonary embolism, thrombolysis, arsenic trioxide.


Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in  APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with thrombolysis for PE and heparin. APL has been processed with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) obtaining complete remission.


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