Main Article Content
Background and objectives: Blood transfusion is a lifesaving therapy for patients with hemoglobinopathies. However, the need of frequent transfusion carries the risk of transmitting hepatitis B and C infections which are intermediately prevalent in Syria. Despite screening blood donations with sensitive methods, the risk of transmission is still present when infectious blood is donated within the window period. This study aimed to investigate the incidence of HBV and HCV seropositivity, and its association with multiple transfusions among Syrian hemoglobinopathies patients.
Materials and Methods: HBsAg, anti-HBc, anti-HBs and anti-HCV were tested for 159 Syrian multitransfused patients by Enzyme Linked Immunosorbant Assay (ELISA).
Results: Thirty-nine of 159 (24.5%) multitransfused patients were HBsAg/anti-HBc or anti-HCV positive, 26 (16%) of which never visited the dentist, and they either tested postsurgically negative for HBsAg and anti-HCV or never underwent a surgical procedure. On the contrary of anti-HCV seropositivity, HBsAg/anti-HBc seropositivity was significantly associated with the number of blood transfusions, number of blood units and age (P < 0.001).
Conclusion: About one-sixth of our patients most likely acquired HBV/HCV infection via blood transfusion. Administering HBV vaccine, ensuring the immune status, and monitoring hepatitis markers might considerably minimize the incidence of viral hepatitis among multitransfused patients.
Downloads month by month
2. Al-Sheyyab M, Batieha A, El-Khateeb M. The prevalence of hepatitis B, hepatitis C and human immune deficiency virus markers in multi-transfused patients. J Trop Pediatr 2001; 47:239-242.
3. Katabuka M, Mafuta ME, Ngoma AM, Beya PM, Yuma S, Aketi L, Kayembe KP, Gini JR. Prevalence and risk factors for hepatitis C virus, hepatitis B virus, and human immunodeficiency virus in transfused children in Kinshasa. Indian J Pediatr 2013; 80:659-62.
4. El-Shanshory MR, Kabbash IA, Soliman HH, Nagy HM, Abdou SH. Prevalence of hepatitis C infection among children with β-thalassaemia major in Mid Delta, Egypt: a single centre study. Trans R Soc Trop Med Hyg 2013; 107:224-8.
5. Shyamala V. Transfusion transmitted infections in thalassaemics: need for reappraisal of blood screening strategy in India. Transfus Med 2014; 24:79-88.
6. Karim M, Lahham H. Prevalence of viral hepatitis B and C in Syria. Syrian Epidemiological Bulletin 2008; 2:10-1.
7. Muselmani W, Habbal W, Monem F. Significance of screening antibodies to hepatitis B virus core antigen among Syrian blood donors. Transfus Med 2013; 23:265-8.
8. Irshad M, Iqbal A, Ansari MA, Raghavendra L. Relation of insulin resistance (IR) with viral etiology and blood level of cytokines in patients with liver diseases. Glo Adv Res J Med Med Sci 2013; 2:75-83.
9. Vidja PJ, Vachhani JH, Sheikh SS, Santwani PM. Blood transfusion transmitted infections in multiple blood transfused patients of beta thalassaemia. Indian J Hematol Blood Transfus 2011; 27:65-9.
10. Karimi M, Ghavanini AA. Seroprevalence of hepatitis B, hepatitis C and human immunodeficiency virus antibodies among multitransfused thalassaemic children in Shiraz, Iran. J Paediatr Child Health 2001; 37:564-6.
11. Ansari SH, Shamsi TS, Khan MT, Perveen K, Farzana T, Erum S, Ansari I. Seropositivity of hepatitis C, hepatitis B and HIV in chronically transfused β-thalassaemia major patients. J Coll Physicians Surg Pak 2012; 22:610-1.
12. El-Faramawy AA, El-Rashidy OF, Tawfik PH, Hussein GH. Transfusion transmitted hepatitis: where do we stand now? a one center study in upper Egypt. Hepat Mon 2012; 12:286-91.
13. Hassanshahi G, Arababadi MK, Assar S, Hakimi H, Karimabad MN, Abedinzadeh M, Rafatpanah H, Derakhshan R. Post-transfusion-transmitted hepatitis C virus infection: a study on thalassemia and hemodialysis patients in southeastern Iran. Arch Virol 2011; 156:1111-5.
14. Shahid S, Ahmad I, Khan M, Khalid F, Ahmad S, Bashir A. Prevalence of HBsAg and anti-HCV antibodies in poly-transfused β-thalassaemia major children in Lahore. Biomedica 2013; 29:230-3.
15. Hassan M, Hasan S, Giday S, Alamgir L, Banks A, Frederick W, Smoot D, Castro O. Hepatitis C virus in sickle cell disease. J Natl Med Assoc 2003; 95:939-42.
16. Sarkari B, Eilami O, Khosravani A, Sharifi A, Tabatabaee M, Fararouei M. High prevalence of hepatitis C infection among high risk groups in Kohgiloyeh and Boyerahmad Province, Southwest Iran. Arch Iran Med 2012; 15:271-4.