HAPTOGLOBIN PHENOTYPES AND SUSCEPTIBILITY OF SCHISTOSOMA PARASITES INFECTION IN CENTRAL SUDAN

Main Article Content

Ashraf Siddig Yousif *
Atif Abdelrahman Elagib
(*) Corresponding Author:
Ashraf Siddig Yousif | ahamadelneel@mgh.harvard.edu

Abstract

Haptoglobin (Hp) is an acute phase protein that binds the free haemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has anti-oxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1 and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study we aimed to assess the possible association of Hp phenotypes polymorphism to Schistosoma parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 S. mansonai, 13 S. haematobium and 19 infected with both ‘’co-infection’’) parasitologically confirmed infected individuals and 208 healthy individuals served as control. Hp phenotypes have been determined by polyacrylamide gel electrophoresis followed by benzidine staining. Our study revealed that Hp1-1 percentage frequency was significantly higher in infected individuals than healthy control individuals 51% and 26% respectively. Our data suggest that Hp1-1 phenotype may upsurge the susceptibility to Schistosoma parasites infection in central Sudan.


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Author Biographies

Ashraf Siddig Yousif, Ragon Institute of MGH, MIT and Harvard University

Ragon Institute of MGH,MIT and Hrvard University

 Researcher Scientist, PhD

Atif Abdelrahman Elagib, National Centre for Research, Ministry of Higher Education and Scientific Research

National Centre for Research, Ministry of Higher Education and Scientific Research 

Professor and Deputy Director of the National Centre for Research, Ministry of Higher Education and Scientific Research 

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