Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

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Isabela Cristina Cordeiro Farias
Taciana Furtado Mendonça-Belmont
Andreia Soares Silva
Kleyton Palmeira do Ó
Felipe Borba Ferreira
Fernanda Silva Medeiros
Luydson Richardson Silva Vasconcelos
Moacyr Jesus Barreto de Melo Rego
Marcos Andre Cavalcanti Bezerra
Aderson Silva Araujo
Patricia Muniz Mendes Freire Moura
Ana Claudia Mendonça Anjos
Betânia Lucena Domingues Hatzlhofer
Maria do Socorro Mendonça Cavalcanti


Sickle cell anemia, vaso-occlusive crisis, splenic sequestration, SOD2 polymorphism


The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology. 


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