Paola Zanotti1*, Claudia Chirico1*, Maurizio Gulletta1, Laura Ardighieri2, Salvatore Casari3, Eugenia Quiros Roldan1, Ilaria Izzo1, Gabriele Pinsi4, Giovanni Lorenzin4,5, Fabio Facchetti2, Francesco Castelli1 and Emanuele Focà1.
1 Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili General Hospital, Brescia, Italy.
2 Pathology Unit, University of Brescia and ASST Spedali Civili General Hospital, Brescia, Italy.
3 Unit of Infectious Diseases, Carlo Poma Hospital, Mantova.
4 Microbiology and Virology Unit, University of Brescia and ASST Spedali Civili General Hospital, Brescia, Italy.
5 Institute of Microbiology and Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy.
*These Authors equally contributed to this work.
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(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
disseminated histoplasmosis (PDH) is an AIDS-defining illness with a
high lethality rate if not promptly treated. The wide range of its
possible clinical manifestations represents the main barrier to
diagnosis in non-endemic countries. Here we present a case of PDH with
haemophagocytic syndrome in a newly diagnosed HIV patient and a
comprehensive review of disseminated histoplasmosis focused on
epidemiology, clinical features, diagnostic tools and treatment options
in HIV-infected patients.
|Figure 1. Representative section of the tonsil showing a prominent sub-epithelial histiocytic infiltrate (hematoxylin and eosin staining, 100X).|
|Figure 2. Tonsil. Cytomorphological details, showing foamy histiocytes containing intracytoplasmic yeasts(hematoxylin and eosin staining, 600X).|
|Figure 3. Tonsil. Grocott's methenamine silver (GMS) stain highlighting intracytoplasmatic fungal elements. (GMS staining, 600X).|
Therapeutic and Preventive Approach