Bortezomib maintenance for the treatment of Monoclonal Gammopathy of Renal Significance

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Holly Lee *
Peter Duggan
Ernesta Paola Neri
Jason Tay
Victor Jimenez Zepeda
(*) Corresponding Author:
Holly Lee |


Monoclonal gammopathy of renal significance (MGRS) defines renal disease resulting from monoclonal proteins that are secreted from clonal B cells, that does not meet criteria for lymphoma or multiple myeloma. Recognizing MGRS in clinical practice is important because renal outcomes are poor and treatments targeting the underlying clonal disease have been associated with improved renal survival. In this case report, we present a case of a patient with membranoproliferative glomerulonephritis (MPGN) with IgG-kappa deposition who underwent clone directed treatment in a phased approach with induction and maintenance to achieve renal response. This is one of the first cases to report on MGRS treatment that required extended maintenance therapy.

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