of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou
University & Henan Cancer Hospital, Zhengzhou, Henan, People's
Republic of China
2 Department of Clinical Laboratory, The Sixth People's Hospital of Zhengzhou City, Zhengzhou, People's Republic of China.
3 Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
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This study aimed to identify the risk factors of candidemia and asses possible clinically significant differences between Candida parapsilosis and other Candida species
in a Chinese tertiary cancer center over six years. A total of 323
cancer patients were enrolled and analyzed from 2012 to 2018. Among the
isolates, the species most frequently isolated was C. parapsilosis (37.15%, 120/323), and C. albicans only accounted for 34.37%. Based on statistical analysis, when candidemia patients who had C. parapsilosis were compared with other Candida spp., the following factors were found to be significantly associated with C. parapsilosis
fungemia: parenteral nutrition (p < 0.001), neutropenia (p <
0.001), receipt of chemotherapy (p = 0.002), and previous antifungal
use (p < 0.001). Parenteral nutrition was a factor that
independently predicted C. parapsilosis candidemia (OR, 0.183; 95% CI, 0.098–0.340; p < 0.001).In short, C. parapsilosis as the leading non-albicans Candida spp.
isolates in candidemia are posing a major threat for cancer patients.
The study highlights the urgent need to evaluate the possibility of
development of C. parapsilosis
candidemia in cancer patients exposed to these risk factors effective
and prevention strategies against this causative agent transmitted
through nosocomial route should be implemented.
Material and Methods
|Table 1. Characteristics of 323 cancer patients with candidemia caused by Candida albicans and C. parapsilosis.|
|Table 2. Factors associated with Candida non-parapsilosis and C. parapsilosis candidemia.a|
|Table 3. Factors associated with non- C. albicans and C. albicans candidemia.a|
|Table 4. In vitro antifungal susceptibility test results of the mainly Candida species.|
|Table 5. Factors associated with 30-day mortality by univariate analysis in candi-demic patients with cancer patients.|
|Table 6. Factors associated with 30-day mortality by multivariate analysis.a|