H1N1 INFECTION IN PREGNANCY; A RETROSPECTIVE STUDY OF FETO-MATERNAL OUTCOME AND IMPACT OF THE TIMING OF ANTIVIRAL THERAPY

Main Article Content

Naser Al-Husban, Dr. Prof. *
Nathir Obeidat, Dr. Prof.
Oqba Al-Kuran, Dr. Prof.
Khaled Al Oweidat, Dr. Prof.
Faris Bakri, Dr. Prof.
(*) Corresponding Author:
Naser Al-Husban, Dr. Prof. | Husban48@yahoo.com

Abstract

Background and Objective: H1N1 infection carries an increased risk in pregnancy. Our aim was to study the fetomaternal outcome and the effect of early initiation of therapy.


Methods: This is a retrospective descriptive study. Confirmed infected cases were included. Maternal age, parity, gestational age at diagnosis, presenting symptoms, time between presentation and starting therapy, ICU admission, and maternal and perinatal outcome were evaluated.


Results: Nineteen confirmed patients were included. Most patients are 31 years old or more. Multiparous patients were 73.68% and 57.89% were in the third trimester. Most of our patients presented with cough, fever, and chills. Two patients were admitted to the ICU. One of them was a case of maternal mortality. 42.10% of patients were started on therapy only one day after clinical onset of symptoms. 26.31% delivered before 37 completed weeks. 73.68% delivered beyond term. Around one third delivered vaginally. 45% of babies weighed more than 3 kg. Four babies weighed less than 2 kg. Ninety percent had APGAR scores more than 8 at 1 and 5 minutes after delivery. Twenty five percent were admitted to the NICU with no neonatal mortalities.


Conclusions: H1N1 influenza A infection in pregnancy is associated with adverse maternal and perinatal outcomes. Medical and public awareness, low threshold for testing suspected pregnant patients, very early initiation of antiviral therapy, and multidisciplinary approach in our series decreased the overall adverse effects of this infection.


 


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Author Biographies

Nathir Obeidat, Dr. Prof., The Obstetrics and Gynecology Department, School of medicine, University of Jordan and Jordan University Hospital, Amman, Jordan

 

 

Oqba Al-Kuran, Dr. Prof., The Respiratory Division, Internal Medicine Department, The School of Medicine, University of Jordan, Amman, Jordan.

Dr  b; Associate Professor in Obstetrics and Gynaecology

Email: 

Khaled Al Oweidata; Assistant Professor

Email; K.oweidat@ju.edu.jo

Dr Faris Bakric; Associate Professor

Email; fbakri@yahoo.com

a; The Respiratory Division, Internal Medicine Department, The School of Medicine,

University of Jordan, Amman, Jordan.

b; The Obstetrics and Gynecology Department, School of medicine, University of Jordan and Jordan University Hospital, Amman, Jordan

c; The Infectious Disease and Vaccine center and Department of Internal Medicine.

The School of medicine, University of Jordan, Amman, Jordan

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