Factors VIII and von Willebrand levels in women undergoing Assisted Reproduction: are their levels associated with clinical pregnancy outcome?

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Monica Attanasio
Michela Cirillo
Maria Elisabetta Coccia
Giancarlo Castaman
Cinzia Fatini


oocyte donation, Factor VIII, Von Willebrand Factor, pregnancy.


A growing number of infertile women are considering pregnancy through assisted reproductive technologies; hormonal fertility treatment is associated with a procoagulant milieu. In oocyte donation Assisted Reproductive Technologies there are patients who experience repeated implantation failures, as well as biochemical pregnancy, in particular in women at advanced age (>40 yrs). No information is available concerning coagulation changes in women undergoing oocyte donation.

In this study, we decided to identify changes in haemostasis in women undergoing infertility treatment and their relationship with clinical pregnancy outcome.

 Our findings evidence an early increase of FVIII and VWF coagulation proteins, suggesting their potential role as early “predictors” of a successful clinical pregnancy in oocyte donation women. This may be intriguing for exploring potential mechanisms responsible for the establishment of a successful pregnancy after oocyte donation.


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