GENETIC PATHWAYS LEADING TO THERAPY-RELATED MYELOID NEOPLASMS

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Angela Stoddart
Megan E. McNerney
Elizabeth Bartom
Rachel Bergerson
David J. Young
Zhijian Qian
Jianghong Wang
Anthony A. Fernald
Elizabeth M. Davis
Richard A. Larson
Kevin P. White
Michelle M. Le Beau

Keywords

therapy-related myeloid neoplasms, genetic pathways, cytogenetic abnormalities, del(5q)

Abstract

Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy.  t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed progenitor cell.  The prognosis for patients with t-MN is poor, as current forms of therapy are largely ineffective.  Cytogenetic analysis, molecular analysis and gene expression profiling analysis of t-MN has revealed that there are distinct subtypes of the disease; however, our understanding of the genetic basis of t-MN is incomplete.  Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies.

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