Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report

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puneet chhabra
arjun dutt law
dr vikas suri
dr pankaj malhotra
dr subhash varma


methotrexate, lung in jury, primary CNS lymphoma


Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.


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