Rubella associated with hemophagocytic syndrome. First report in a male and review of the literature

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Makram Koubaa
Chakib Marrakchi
Imed Mâaloul
Saloua Makni
Lamia Beraajah
Moez Elloumi
Boussaima Hammami
Dorra Lahiani
Tahia Boudawara
Mounir Ben Jemâa


Rubella, Male, Hemophagocytic syndrome


A 22-year-old man was admitted to our hospital because of fever, skin rash and epistaxis. Physical examination revealed fever (39.5°C), generalized purpura, lymphadenopathy and splenomegaly. Blood tests showed pancytopenia. Bone marrow aspiration and biopsy showed hemophagocytosis with no evidence of malignant cells. Anti rubella IgM antibody were positif and the IgG titers increased from 16 to 50 UI/mL in 3 days. Therefore, he was diagnosed to have rubella-associated hemophagocytic syndrome. We report herein the first case in a man and the sixth case of rubella-associated hemophagocytic syndrome in the literature by search in Pub Med till March 2012.


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