MJHID Educational Clinical Cases
Vol. 7 (2015): Review Series, Original Articles, Case Reports

An unusual cause of anemia and encephalopathy

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Received: March 16, 2015
Accepted: April 6, 2015
Published: April 24, 2015
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Hematology, oncology

Authors

The authors present here an interesting case of recent onset anemia that was associated with an encephalopathy of the unusual cause.Although severe anemia can theoretically result in anemic hypoxia and can then lead to hypoxic encephalopathy, it is not a primary cause of encephalopathy. More frequently anemia can contribute together with other multiple causes of encephalopathy, such as infections, metabolic abnormalities, trauma, hepatic dysfunction, hypertension, toxins. 

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References
Schluterman KO, Fassas AB, Van Hemert RL, Harik SI. Multiple myeloma invasion of the central nervous system. Arch Neurol. 2004;61:1423-29. doi:10.1001/archneur.61.9.1423, PMid:15364689
Lora-Tamayo J, Palom X, Sarrá J. Multiple myeloma and hyperammonemic encephalopathy: review of 27 cases. Clin Lymphoma Myeloma. 2008;8:363-69. doi: 10.3816/CLM.2008.n.054, PMid:19064403
Kwan L, Wang C, Levitt L. Hyperammonemic Encephalopathy in Multiple Myeloma. N Engl J Med. 2002;346:1674-75. PMid:12024007
Martinelli G, Peccatori F, Ullrich B, Ghielmini M, Roggero E, Goldhirsch A. Clinical manifestation of severe hyperammonaemia in patients with multiple myeloma. Ann Oncol. 1997;8:811. PMid:9332693
Matsuzaki H, Hata H, Sonoki T, Matsuno F, Kuribayashi N, Yoshida M, Nagasaki A, Murata H, Fujiyama S, Takatsuki K. Serum amino acid disturbance in multiple myeloma with hyperammonemia. Int J Haematol. 1995; 61:131-37. PMid:7599324
Holahan JR. Hyperammonemia: elevated ammonia levels in multiple myeloma. Am J Med. 2004;116:210-11. doi: http://dx.doi.org/10.1016/j.amjmed.2003.06.010, PMid:14749172
Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Roman M, Kiwan E, Krishna S, Tricot G. Hyperammonemia and encephalopathy in patients with multiple myeloma. Am J Hematol. 2007; 82:414-15. PMid:17133420
Otsuki T, Yamada O, Sakaguchi H, Ichiki T, Kouguchi K, Wada H, Hata H, Yawata Y, Ueki A. In vitro excess ammonia production in human myeloma cell lines. Leukemia. 1998;12:1149-58. PMid:9665203
Pham A, Reagan JL, Castillo JJ. Multiple myeloma-induced hyperammonemic encephalopathy: An entity associated with high in-patient mortality. Leuk Res. 2013;37:1229-32. doi: 10.1016/j.leukres.2013.07.014, PMid: 23932549

Ethics Approval

Educational case report

Supporting Agencies

None
Sanjeev Kumar Sharma, MD

Consultant and Principal Coordinator

Department of Hemato-oncology and bone marrow transplantation

New Delhi

How to Cite



“An unusual cause of anemia and encephalopathy” (2015) Mediterranean Journal of Hematology and Infectious Diseases, 7(1), p. e2015036. doi:10.4084/mjhid.2015.036.