Leukocyte derived chemotaxin 2 (ALECT2) amyloidosis

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Uday P Kulkarni
Anna Valson
Anila Korula
Vikram Mathews


Amyloidosis, ALECT2, renal amyloid, ethnic variation, treatment


We describe the first case from India of ALECT2 amyloidosis. An adult Punjabi male presented with progressive renal dysfunction and non-nephrotic range proteinuria. Serum protein electrophoresis and Immunofixation were normal, with mildly elevated serum free light chain ratio. Renal biopsy confirmed the presence of amyloid. Immunohistochemistry was negative for monoclonal light chains. Proteomic analysis confirmed the presence of ALECT2 amyloid. The present case highlights the need for confirmatory testing for typing of amyloid.


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