Ponatinib induced improvement of cutaneous lesions associated to accelerated phase of Ph-positive chronic myeloid leukemia

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Massimo Breccia
Gioia Colafigli
Luisa Quattrocchi
elisabetta abruzzese
giuliana alimena


CML, ponatinib, extramedullary localization


Ponatinib a third generation tyrosine kinase inhibitor, has been approved for all phases of disease in CML. In advanced phase, has been confirmed with a good efficacy in all type of resistance, including T315I kinase domain mutation. We here report activity of the drug in advanced phase with extramedullary localization.


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