Original Articles
Vol. 9 No. 1 (2017): Review, Original Articles, Case Reports
https://doi.org/10.4084/mjhid.2017.042

HAPTOGLOBIN PHENOTYPES AND SUSCEPTIBILITY OF SCHISTOSOMA PARASITES INFECTION IN CENTRAL SUDAN

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: March 26, 2017
Accepted: June 8, 2017
Published: July 1, 2017
3043
Views
648
Downloads
936
HTML
, Haptoglobin, Polymorphism, Schistosoma, Infection and Susceptibility
Infectious Diseases, parasitology

Authors

Ashraf Siddig Yousif
ahamadelneel@mgh.harvard.edu
Ragon Institute of MGH, MIT and Harvard University, United States.
Atif Abdelrahman Elagib
National Centre for Research, Ministry of Higher Education and Scientific Research, Sudan.

Haptoglobin (Hp) is an acute phase protein that binds the free haemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has anti-oxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1 and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study we aimed to assess the possible association of Hp phenotypes polymorphism to Schistosoma parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 S. mansonai, 13 S. haematobium and 19 infected with both ‘’co-infection’’) parasitologically confirmed infected individuals and 208 healthy individuals served as control. Hp phenotypes have been determined by polyacrylamide gel electrophoresis followed by benzidine staining. Our study revealed that Hp1-1 percentage frequency was significantly higher in infected individuals than healthy control individuals 51% and 26% respectively. Our data suggest that Hp1-1 phenotype may upsurge the susceptibility to Schistosoma parasites infection in central Sudan.

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Alayash AI. Haptoglobin: Old protein with new functions. Vol. 412, Clinica Chimica Acta. 2011. p. 493–8. http://www.sciencedirect.com/science/article/pii/S0009898110007576
Fagoonee S, Gburek J, Hirsch E, Marro S, Moestrup SK, Laurberg JM, et al. Plasma protein haptoglobin modulates renal iron loading. Am J Pathol [Internet]. 2005;166(4):973–83. Available from: http://dx.doi.org/10.1016/S0002-9440(10)62319-X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602399/
Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Vol. 42, Clinical Chemistry. 1996. p. 1589–600. https://www.ncbi.nlm.nih.gov/pubmed/8855140
Speeckaert R, Brochez L, Lambert J, van Geel N, Speeckaert MM, Claeys L, et al. The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients. J Eur Acad Dermatol Venereol [Internet]. 2012;26(5):566–71. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21575065
Kasvosve I, Speeckaert MM, Speeckaert R, Masukume G, Delanghe JR. Haptoglobin polymorphism and infection. Vol. 50, Advances in clinical chemistry. 2010. p. 23–46. http://www.sciencedirect.com/science/article/pii/S0065242310500027
Mahmud SM, Koushik A, Duarte-Franco E, Costa J, Fontes G, Bicho M, et al. Haptoglobin phenotype and risk of cervical neoplasia: A case-control study. Clin Chim Acta. 2007;385(1–2):67–72. http://www.sciencedirect.com/science/article/pii/S000989810700366X
Napolioni V, Giannì P, Carpi FM, Concetti F, Lucarini N. Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population. Clin Chim Acta. 2011;412(7–8):574–7. https://www.ncbi.nlm.nih.gov/pubmed/21147083
Deganello, R., Cruciani, M., Beltramello, C., Duncan, O., Oyugi, V. and Montresor A. Schistosoma haematobium and Schistosoma mansoni among children, Southern Sudan. Emerg Infect Dis. 2007;13:1–5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851532/
Elhag SM, Abdelkareem EA, Yousif AS, Frah EA, Mohamed AB. Detection of schistosomiasis antibodies in urine patients as a promising diagnostic maker. Asian Pac J Trop Med. 2011;4(10):773–7. https://www.ncbi.nlm.nih.gov/pubmed/22014731
Sleigh A, Xueming Li, Jackson S, Huang K. Eradication of schistosomiasis in Guangxi, China. Part 3. Community diagnosis of the worst-affected areas and maintenance strategies for the future. Bull World Health Organ. 1998;76(6):581–90. https://www.ncbi.nlm.nih.gov/pubmed/10191554
Ibrahim N, Baleela R. Association of Hp 1-1 with liver disorders among Sudanese patients. Am J Sci Ind Res [Internet]. 2012;3(6):403–5. Available from: http://www.scihub.org/AJSIR
Rania M. H. Baleela; Nada E. Ibrahim; Omran F. Osman and Atif A. Elagib2. Distribution of Haptoglobin Phenotypes among Patients with HIV/AIDS, Hepatitis B, Liver Cirrhosis and Chronic Renal Failure in Sudan. Sudan J Sci. 2012;5(1):1–6. http://khartoumspace.uofk.edu/handle/123456789/22372
Elagib AA, Kider AO, Åkerström B, Elbashir MI. Association of the haptoglobin phenotype (1-1) with falciparum malaria in Sudan. Trans R Soc Trop Med Hyg. 1998;92(3):309–11. https://www.ncbi.nlm.nih.gov/pubmed/9861405
Yousif AS, Abdelkareem E a., Elhag SM, Elgimeaabi L a., Ahmed M a., Frah E a., et al. Circulating antigens of Schistosoma parasites in urine of schistosomiasis patients in Central Sudan. J Infect Dis Immun [Internet]. 2009;1(2):011–5. Available from: http://www.academicjournals.org/journal/JIDI/article-abstract/0F9FF8C4263
Davis. I. and Orenstein. J. DISC electrophporesis, Acrylamide gel columns. Vol. 2, Methods in immunology and immunochemistry. 1968. 38-47 p.
Linke RP. Typing and subtyping of haptoglobin from native serum using disc gel electrophoresis in alkaline buffer: Application to routine screening. Anal Biochem. 1984;141(1):55–61. https://www.ncbi.nlm.nih.gov/pubmed/6496936
Chapman SJ, Hill A V. Human genetic susceptibility to infectious disease. Nat Rev Genet [Internet]. 2012;13(3):175–88. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22310894
Brouwer MC, de Gans J, Heckenberg SG, Zwinderman AH, van der Poll T, van de Beek D. Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Vol. 9, The Lancet Infectious Diseases. 2009. p. 31–44. https://www.ncbi.nlm.nih.gov/pubmed/19036641
Speeckaert R, Colebunders B, Boelaert JR, Brochez L, Van Acker J, Van Wanzeele F, et al. Association of haptoglobin phenotypes with the development of Kaposi’s sarcoma in HIV patients. Arch Dermatol Res. 2011;303:763–9. http://link.springer.com/article/10.1007/s00403-011-1161-9
Vitalis Z, Altorjay I, Tornai I, Palatka K, Kacska S, Palyu E, et al. Phenotypic polymorphism of haptoglobin: A novel risk factor for the development of infection in liver cirrhosis. Hum Immunol. 2011;72(4):348–54. https://www.ncbi.nlm.nih.gov/pubmed/21262313
Mundaray Fernández N, Fernández-Mestre M. The Role of haptoglobin genotypes in Chagas disease. Dis Markers. 2014;2014:1–6. https://www.hindawi.com/journals/dm/2014/793646/
Perdijk O, Arama C, Giusti P, Maiga B, Troye-Blomberg M, Dolo A, et al. Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali. Malar J [Internet]. 2013;12(1):432. Available from: http://www.malariajournal.com/content/12/1/432
Quaye IKE, Ekuban FA, Goka BQ, Adabayeri V, Kurtzhals JAL, Gyan B, et al. Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg [Internet]. 2000;94(2):216–9. Available from: http://trstmh.oxfordjournals.org.ezp.lib.unimelb.edu.au/content/94/2/216
Tseng CF, Lin CC, Huang HY, Liu HC, Mao SJT. Antioxidant role of human haptoglobin. In: Proteomics. 2004. p. 2221–8. https://www.ncbi.nlm.nih.gov/pubmed/15274115
Cook RM, Carvalho-Queiroz C, Wilding G, LoVerde PT. Nucleic acid vaccination with Schistosoma mansoni antioxidant enzyme cytosolic superoxide dismutase and the structural protein filamin confers protection against the adult worm stage. Infect Immun. 2004;72(10):6112–24. https://www.ncbi.nlm.nih.gov/pubmed/15385516

Ethics Approval

Original Article

Supporting Agencies

National Centre for Research (NCR), Ministry of Higher Education and Scientific Research- Sudan
Ashraf Siddig Yousif, Ragon Institute of MGH, MIT and Harvard University

Ragon Institute of MGH,MIT and Hrvard University

 Researcher Scientist, PhD
Atif Abdelrahman Elagib, National Centre for Research, Ministry of Higher Education and Scientific Research

National Centre for Research, Ministry of Higher Education and Scientific Research 

Professor and Deputy Director of the National Centre for Research, Ministry of Higher Education and Scientific Research 

How to Cite



“HAPTOGLOBIN PHENOTYPES AND SUSCEPTIBILITY OF SCHISTOSOMA PARASITES INFECTION IN CENTRAL SUDAN” (2017) Mediterranean Journal of Hematology and Infectious Diseases, 9(1), p. e2017042. doi:10.4084/mjhid.2017.042.