Case Reports
Vol. 10 (2018): Review Articles, Original Articles, Scientific Letters, Case Reports
Genomic integration of HHV-6 mimicking viral reactivation after autologous stem cell transplantation
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: October 3, 2017
Accepted: January 31, 2018
Accepted: January 31, 2018
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Hematology-Infectious Disease-Molecular Biology
Authors
The monitoring of HHV-6 after allogeneic hematopoietic stem cell transplantation (HSTC) has proven to be useful in preventing life-threatening complications; however, the pathogenic role of HHV-6 after autologous HSCT is not well-characterized, although viral reactivation might be responsible for significant complications even after autologous HSCT. Here we report for the first time to our knowledge the case of a patient with genomic integration of HHV-6, presenting with high titers of HHV-6 after autologous HSCT, mimicking HHV-6 reactivation. The presence of viral DNA in the follicle bulb confirmed the genomic integration and allowed the discontinuation of the antiviral treatment to the patient. This case might be helpful for discriminate HHV-6 reactivation from viral integration, thus avoiding unnecessary and potentially toxic antiviral therapy once the genomic integration is confirmed.
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Citations
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Case ReportHow to Cite
“Genomic integration of HHV-6 mimicking viral reactivation after autologous stem cell transplantation” (2018) Mediterranean Journal of Hematology and Infectious Diseases, 10(1), p. e2018013. doi:10.4084/mjhid.2018.013.
