THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES

Main Article Content

Giovanni Roti
University of Parma, Department of Medicine and Surgery

Claudia Sorrentino
University of Parma, Department of Medicine and Surgery, Parma, 43126, Italy

Antonio Cuneo
University of Ferrara, Department of Medical Sciences, Ferrara, 44121, Italy

Keywords

NOTCH1, Targeted therapy, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, mantle cell lymphoma

Abstract

The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients’ outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia and mantle cell lymphoma.

Downloads

Download data is not yet available.


Abstract 1616
PDF Downloads 1293
HTML Downloads 229

References

We would recommend these colleagues as potential referees:

Prof. Cristina Mecucci, M.D.; Ph.D.
University of Perugia
cristina.mecucci@unipg.it

Dr. Sabina Chiaretti
University “La Sapienza” of Roma
chiaretti@bce.uniroma1.it

Article Sidebar

PDF HTML
Published
Jun 25, 2019
DOI https://doi.org/10.4084/mjhid.2019.037

Article Details

How to Cite

Roti, G., Sorrentino, C. and Cuneo, A. (2019) “THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES”, Mediterranean Journal of Hematology and Infectious Diseases, 11(1), p. e2019037. doi: 10.4084/mjhid.2019.037.
Issue
Vol. 11 No. 1 (2019): Review Articles, Original Articles, Scientific Letters, Case Reports, Letters to Editor.
Section
Review Articles

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Transfer of Copyright and Permission to Reproduce Parts of Published Papers. Authors will grant copyright of their articles to the Institute of Hematology, Catholic University, Rome . No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.