Case Reports
Vol. 12 No. 1 (2020): Mediterranean Journal of Hematology and Infectious Diseases, Volume 12, 2020
https://doi.org/10.4084/mjhid.2020.035

The First Case of Concomitant Mycobacterium genavense lymphadenitis and EBV-positive lymphoproliferative disorder

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Received: February 14, 2020
Accepted: May 24, 2020
Published: June 28, 2020
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Authors

Yusuke Ito
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
Kensuke Takaoka
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
Kazuhiro Toyama
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
Yoshitaka Wakabayashi
Department of Infectious Diseases, The University of Tokyo Hospital, Japan.
Aya Shinozaki-Ushiku
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan.
Aiko Okazaki
Department of Infectious Diseases, The University of Tokyo Hospital, Japan.
Kinuyo Chikamatsu
Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Japan.
Satoshi Mitarai
Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Japan.
Tetsuo Ushiku
Department of Pathology, Graduate School of Medicine, The University of Tokyo, Japan.
Mineo Kurokawa
kurokawa-tky@umin.ac.jp
a:1:{s:5:"en_US";s:23:"The University of Tokyo";}, Japan.

This is the first case of concurrent Mycobacterium genavense lymphadenitis and Epstein-Barr virus (EBV)-positive lymphoproliferative disorder (LPD) in the same lymph node with no immunocompromised history. M. genavense infection is a rare opportunistic infection mainly for human immunodeficiency virus (HIV)-infected patients. Although no immunodeficiency was detected in our patient, our case indicates that the immunodeficiency in the background of EBV latency type III and the immunosuppression by malignant lymphoma itself might induce the M. genavense lymphadenitis. This case highly alerts clinicians the immunosuppressive state of EBV-positive LPD with latency type III even if any serological immunodeficient factors are not detected.

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“The First Case of Concomitant Mycobacterium genavense lymphadenitis and EBV-positive lymphoproliferative disorder” (2020) Mediterranean Journal of Hematology and Infectious Diseases, 12(1), p. e2020035. doi:10.4084/mjhid.2020.035.